海洋来源放线菌中新生物碱成分研究进展

Review on Alkaloids from Marine-derived Actinomycetes

因其独特的生活环境,海洋来源的放线菌具有新颖的代谢途径。近年来从海洋来源的放线菌分离出大量的生物碱,具有独特的化学结构与多种生物活性,有些已进入临床前研究。这些活性生物碱为药物研发提供了丰富的先导化合物。本文介绍了2010年以来国内外报道的海洋来源放线菌中新生物碱的化学结构、来源与生物活性,旨在对海洋来源放线菌生物碱的研究奠定基础。

Due to the unique living environment,marine-derived actinomycetes have novel metabolic pathways.In recent years,many alkaloids with remarkable activity and novel structure have been found from marine-derived actinomycetes,some of which have entered into the pre-clinical research.These active alkaloids provide tremendous lead compounds for drug discovery and development.In order to lay the foundation for the research of marine derived actinomycetes alkaloids,the chemical structure,source and biological activity of the new alkaloids from marine-derived actinomycetes since 2010 were introduced.