全聋型突发性聋高压氧早期治疗的有效性研究

Effect of early hyperbaric oxygen therapy on patients with profound sudden hearing loss

目的探讨早期高压氧合并药物治疗全聋型突发性聋(简称突聋)的有效性。方法以本院2013年1月~2014年5月收治的全聋型突聋患者为研究对象,按照中国突聋多中心临床研究的入组方式、疗效评判标准,与其中的全聋型突聋组疗效进行比较。结果本院全聋型突聋的治愈率为17.6%,与多中心全聋型突聋的总体(14.4%)和多中心三联药物组(16.8%)接近;显效率为56.9%,高于多中心全聋型突聋的总体(28.3%)和三联药物组(27.7%);总显效率为74.5%,远高于多中心全聋型突聋的总体(42.7%;χ~2=42.15,P=0.000)和三联药物组(44.6%;χ~2=21.04,P=0.000)。本院全聋型突聋治疗前的平均听阈为(101.8±13.5)d B,治疗后为(61.5±25.3)d B;多中心全聋型突聋治疗前的平均听阈为(98.5±13.6)d B,治疗后为(64.0±29.5)dB。结论尽早采用高压氧合并药物治疗,可以提高全聋型突聋患者的疗效。

Objective To evaluate the effect of early hyperbaric oxygen therapy combined with conventional medicine on patients with profound sudden hearing loss. Methods Patients with profound sudden hearing loss were recruited during January 2013 to May 2014. The inclusion and evaluation criteria were referred to the chinese guideline （2015） of diagnosis and treatment of sudden hearing loss, and the outcomes in the present study were compared with the outcomes of Chinese multi-center study. Results Complete recovery for patients with profound sudden hearing loss was 17.6% in the present study, which was comparable with the outcomes in the multicenter study. In addition, marked improvement for patients with profound sudden hearing loss in the present study was 56.9%, which was greater than that in the muhicenter study （28.3%）. Furthermore, the total marked improvement in the present study was 74.5%, which was superior to the total marked improvement of 42.7% in the muhicenter study, and the difference was significant （χ^2 =42.15, P = 0. 000）. Furthermore, the initial hearing threshold was （ 101.8 ± 13.5 ） dB and post treatment hearing threshold was （61.5 ±25.3 ） dB in the present study. The initial hearing threshold was （98.5 ±13.6） dB and the post treatment hearing threshold was （64.0 ± 29.5 ） dB in the muhicenter study. Conclusions Early hyperbaric oxygen therapy combined with conventional medicine was able to achieve better outcomes in patients with profound sudden hearing loss. （Chin J Ophthalmol and Otorhinolaryngol,2017 ,17 ：19-22）