摘要
头颈鳞状细胞癌(HNSCCs)是人体常见恶性肿瘤之一,发病率呈逐年上升趋势,但其发病机制目前尚不清楚。近年来研究发现,细胞核内、外的P27蛋白异常表达,可通过不同的信号转导机制,在多种HNSCCs细胞的浸润和迁移等病理过程中发挥不同的调控作用,从而影响HNSCCs患者的预后。本文综述P27蛋白在HNSCCs临床病理特征及预后判断中的研究进展。
Head and neck squamous cell carcinoma （HNSCCs） is one of the common human malignant tumors. Its incidence is increasing year by year, but its pathogenesis is still unclear. The current studies have found that the abnormal expression of P27 molecule in the nucleus and cytoplasm play different regulatory roles in various pathological processes including invasion and migration of HNSCCs cells through different signal transduction mechanisms, which affect the prognosis of patients with HNSCCs. Therefore, this article will review the research progress of P27 protein in the clinicopathological characteristics and prognosis of HNSCCs. （ Chin J Ophthalmol and Otorhinolaryngol, 2017,17：68-70 ）
出处
《中国眼耳鼻喉科杂志》
2017年第1期68-70,76,共4页
Chinese Journal of Ophthalmology and Otorhinolaryngology
基金
浙江省医药卫生科技计划项目(2015KYB292)
南京医科大学科技发展基金重点项目(2015NJMUZD087)
关键词
P27蛋白
头颈鳞状细胞癌
病理机制
预后
P27 protein
Head and neck squamous cell carcinomas
Pathological mechanism
Prognosis
