ALDH2基因多态性与中国人缺血性脑卒中关系的Meta分析

Genetic polymorphism in ALDH2 and risk of Chinese people with ischemic stroke: a meta-analysis

目的系统评价ALDH 2基因多态性与缺血性脑卒中的关系。方法计算机检索Web of Science、Pub Med、CNKI、CBM和Wan Fang Data数据库,搜集ALDH 2基因多态性与缺血性脑卒中相关性的病例-对照研究,检索时限从建库至2016年10月。由2名研究者分别独立按照纳入与排除标准筛选文献、提取资料并评价纳入研究的偏倚风险后,采用Stata 12.0软件进行数据分析。结果共纳入7个病例-对照研究,Meta分析结果显示ALDH 2 A等位基因及AA基因型与中国人缺血性脑卒中患病相关[A vs.G:OR=1.430,95%CI(1.006,2.033),P=0.046;AA vs.AG+GG:OR=1.734,95%CI(1.267,2.373),P=0.001;AA vs.GG:OR=1.757,95%CI(1.274,2.424),P=0.001]。结论 ALDH 2基因多态性与中国人缺血性脑卒中有关,A等位基因是其潜在危险因素。

Objective To systematically review the association between ALDH2 polymorphism and ischemic stroke. Methods Web of Science, PubMed, CNKI, CBM and WanFang data were searched to collect case-control studies about the association between ALDH2 polymorphism and ischemic stroke from the inception to October 2016. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies. Then metaanalysis was performed by using Stata 12.0 software. Results A total of seven case-control studies were included. The results of meta-analysis showed that the A allele and AA genotype in ALDH2 was associated with the risk of ischemic stroke （A vs. G： OR=1.430, 95%CI 1.006 to 2.033, P=0.046; AA vs. AG＋GG： OR=1.734, 95%CI 1.267 to 2.373, P=0.001; AA vs. GG： OR=1.757, 95%CI 1.274 to 2.424, P=0.001）. Conclusion ALDH2 gene polymorphism may related to ischemic stroke for Chinese and A allele of ALDH2 may be the risk factors.