心肌梗死及其预后与心肌酶谱、红细胞参数的相关性研究

Study on the Correlation of Prognosis of Myocardial Infarction with Myocardium Zymogram and Parameters of Red Blood Cells

目的探讨心肌梗死患者预后情况与红细胞参数及心肌酶谱的相关性。方法选取我院收治的冠心病患者120例,其中稳定型心绞痛40例,不稳定型心绞痛40例以及心肌梗死40例,同期选取以"胸痛"为症状且经检查和诊断排除冠心病的患者40例作为对照组。对上述四组患者的心肌酶谱与红细胞参数进行检测,分析心肌酶谱与红细胞参数对心肌梗死患者预后的相关性。结果四组患者的红细胞形态学参数(MCV、MCH、MCHC以及RDW)比较均有统计学差异(P<0.05)。四组患者的心肌酶谱水平(cTnT、cTn I、CK-MB、LDH以及AST水平)比较均有统计学差异(P<0.05)。心肌梗死组患者10 d内的红细胞形态学参数(MCV、MCH、MCHC以及RDW)明显提高(P均<0.05)。结论心肌梗死与体内红细胞形态学参数和心肌酶指标水平密切相关,因此红细胞形态学参数和心肌酶指标水平可作为临床上诊断该疾病严重程度的手段。

Objective To explore correlation between the prognosis of patients with myocardial infarction and red blood cellparameters and myocardium zymogram. Methods 120 cases of patients with coronary heart disease admitted to our hospital were selected,including 40 patients with stable angina, 40 patients with unstable angina and 40 cases patients with myocardial infarction, at the same time,40 cases of patients with the symptom of chest pain were ruled out coronary heart disease by examination and diagnosis and selected ascontrol group. The myocardium zymogram and red blood cell parameters of patients in above four groups were detected, and correlationbetween the prognosis of patients with myocardial infarction and red blood cell parameters and myocardium zymogram was analyzed.Results The erythrocyte morphological parameters （MCV, MCH, MCHC and RDW） had statistical differences among four groups （P〈0.05）.The myocardium zymogram （cTnT, cTnI, CK-MB, LDH and AST levels） had statistical differences among four groups （P 〈0.05）. Theerythrocyte morphological parameters （MCV, MCH, MCHC and RDW） of patients with myocardial infarction within 10 days significantlyincreased （all P 〈0.05）. Conclusions The myocardial infarction is closely relative to the erythrocyte morphological parameters andmyocardium zymogram level. So the erythrocyte morphological parameters and myocardium zymogram level can be used in the clinicaldiagnosis of disease severity.