肠易激综合征的病理机制研究进展

Advances in the pathogenesis of irritable bowel syndrome

肠易激综合征发病机制未明,通常认为可能与肠道动力紊乱、内脏高敏、精神心理等多种因素有关。近年来大量研究发现肠道低度炎症、脑-肠轴、神经-内分泌-免疫可能在IBS的发病中起重要作用。因此本文针对近年来发病机制的研究进展作一综述。

The mechanism of irritable bowel syndrome（IBS） is still unknown, which may be related to abnormal intestinal motility, visceral hypersensitivity, psychological factors and so on. Studies in recent years have demonstrated that low-grade inflammation, brain-gut axis and neuro-endocrine-immune regulation may play important roles in the pathogenesis of IBS. In this paper we will review recent research advances in the pathogenesis of IBS.