不同经穴针刺对自发性高血压大鼠降压效应的观察

Anti-hypertensive Effect of Acupuncture at Different Acupoints on Spontaneously Hypertensive Rats

【目的】探讨不同经穴针刺对自发性高血压大鼠(SHR)的降压效应及累积效应。【方法】将105只SHR随机分为模型组、非穴组、内关组、太冲组、光明组、太溪组、蠡沟组,每组15只。各针刺组以毫针刺入相应穴位后,留针30 min,每日1次,共15次;模型组不予针刺。各组大鼠分别在针刺l、3、7、15 d时进行血压测量。【结果】非穴针刺无明显降压作用。针刺3、7、15 d时,太冲组、内关组、光明组SHR收缩压(SBP)、舒张压(DBP)、平均动脉压(MBP)下降幅度均显著大于模型组,差异有统计学意义(P<0.05);针刺15 d时,太冲组SBP降幅显著优于内关组、蠡沟组、太溪组、光明组,差异有统计学意义(P<0.05);太冲组DBP、MBP降幅显著高于太溪组、光明组(P<0.05),与内关组、蠡沟组大鼠DBP比较差异无统计学意义(P>0.05)。与治疗前比较,针刺1、3、7、15 d时,太冲组SBP、DBP、MBP显著下降,差异均有统计学意义(P<0.05),其中针刺15 d时SBP降幅优于针刺1 d、3 d、7 d,DBP、MBP降幅优于针刺1、3 d,差异均有统计学意义(P<0.05)。【结论】针刺太冲穴对SHR血压的调节作用优于针刺内关、太冲、光明、太溪、蠡沟等单穴和"非穴",且针刺降压作用具有一定的时间累积效应。

Objective To observe the anti-hypertension effect of acupuncture at different acupoints on the spontaneously hypertensive rats（SHRs）, and to explore the antihypertensive effect and accumulated effect of different acupoints. Methods One hundred and five SHRs were randomized into model group,non-acupoint group, Neiguan（PC6）group, Taichong（LR3）group, Guangming（GB3）group, Taixi（KI3）group and Ligou（LR5）group,15 rats in each group. The acupuncture needles for acupoint groups were retained in acupoints for30 min each time,once per day,15 times in total. The model group had no acupuncture treatment. The blood pressure was examined on the day one, 3, 7 and 15 of the acupuncture treatment. Results The non-acupoint group had no significant anti-hypertension effect. On the day 3, 7 and 15 of the acupuncture treatment, the reduction of systolic blood pressure（SBP）, diastolic blood pressure（DBP） and mean arterial blood pressure（MBP） in Neiguan group,Taichong group,Guangming group was greater than that in the model group,the differences being statistically significant（P 0.05）. On the day 15, the reduction of SBP in Taichong group was superior to that of Neiguan group,Ligou group,Taixi group and Guangming group（P 0.05）,and the reduction of DBP and MBP in Taichong group was superior to that of Taixi group and Guangming group（P 0.05）,but the reduction of DBP in Taichong group did not differ from that in Neiguan group and Ligou group（P 0.05）. On the day one,3,7 and 15,SBP,DBP and MBP in Taichong group were decreased（P 0.05 compared with those before treatment）, and the reduction of SBP on the day 15 was significantly better than that on the day1,3 and 7,while the reduction of DBP and MBP on the day 15 was significantly better than that on the day 1and 3（P 0.05）. Conclusion Acupuncture at Taichong has better anti-hypertension effect than other single acupoint including Neiguan,Taichong,Guangming,Taixi,Ligou and non-acupoint,and the anti-hypertension action of acupuncture is an accumulative effect.