覆膜支架腔内修复术治疗Stanford B型主动脉夹层动脉瘤临床研究

Endovascular Stent Graft Repair for the Treatment of Stanford B Aortic Dissection

目的:探究与分析覆膜支架腔内修复术治疗Stanford B型主动脉夹层动脉瘤的临床效果。方法:回顾性分析我院自2011年1月至2016年1月收治的Stanford B型主动脉夹层动脉瘤患者90例临床资料,按照治疗方法的不同分为对照组与观察组,对照组给予药物保守治疗,观察组给予覆膜支架腔内修复术治疗,对比两组患者随访12个月期间并发症发生率、死亡率、再次手术或介入治疗的干预率、IL-1β、INF-γ、NF-k B、VEGF表达水平及生活质量。结果:随访12个月观察组较对照组相比并发症发生率、死亡率及再次手术或介入率均较低,差异具有统计学意义(P<0.05)。两组患者治疗后较治疗前相比IL-1β、INF-γ、NF-k B及VEGF mRNA表达水平均降低,观察组较对照组相比上述指标改善更加显著,差异具有统计学意义(P<0.05)。观察组较对照组相比躯体功能、角色功能、情感功能、认知功能及社会功能评分相比均较高,差异具有统计学意义(P<0.05)。结论:采用覆膜支架腔内修复术治疗Stanford B型主动脉夹层动脉瘤的临床效果显著,随访期间并发症发生率及死亡率较低,生存率较高,可改善患者的生活质量。

Objective：To study and analyze coated stent graft repair for treatment of stanford type B aortic dissecting aneurysm. Methods：The clinical data of 90 patients with stanford type B aortic dissection an-eurysm admitted in our hospital from Janurary 2011 to Janurary 2016 were analyzed. According to the time se-quence, all the patients were divided into control group and observation group, control group was given medi-cine conservative treatment, the observation group was given coated stent lumen repair treatment. During the 12-month-followed-up for patients of two groups, the incidence of complications, mortality, reoperation or intervention treatment, IL-1β, INF-γ, NF-kB, VEGF expression levels and quality of life were compared. Results：The incidence of complications, mortality, reoperation or intervention treatment,IL-1β, INF-γ, NF-kB, VEGF expression levels and quality of life of the observation group were lower than that of the control group. And difference had statistically significant （ P 〈0.05） . Comparing the patients of two groups after treat-ment than before treatment, IL-1β, INF-γ,NF-kB,VEGF mRNA expression level were lower, observation group improved more significantly than the control group. Compared with the above indicators, the results had the statistically significant difference （P 〈 0.05）. The physical function, role function, emotional function, cognitive function and social function score of observation group were higher than the control group. The results had statistically significant difference （ P 〈0.05） . Conclusion：Using coated stent lumen Stanford type B aor-tic dissecting aneurysm repair has the significant clinical effect, lower incidence of complications and mortality during the follow-up period, high survival rate. And it can improve the patient＆#39;s quality of life.