非酒精性脂肪肝患者肾素-血管紧张素系统变化及缬沙坦胶囊对其影响的研究

The Change of Renin-angiotensin System in Patients with Nonalcoholic Fatty Liver Disease

目的:探讨非酒精性脂肪肝(nonalcoholic fatty liver disease,NAFLD)患者血浆中的肾素-血管紧张素系统(renin-angiotensin system,RAS)在疾病变化过程中的关系,并进行相关分析。方法:随机收集于我院就诊的经过临床相关血液指标、肝脏彩超等临床诊断确诊的88例NAFLD患者做为NAFLD组,同时选取90例健康体检者为对照组做为对比参照,NAFLD组采用口服缬沙坦胶囊进行干预治疗,在治疗干预前后分别检测患者血浆中丙氨酸氨基转移酶(ALT)、谷氨酰基转移酶(GGT)、甘油三酯(TG)、总胆固醇(TCHO)、空腹血糖(GLU)、肾素活性(Plasma renin activity,PRA)、血管紧张素Ⅰ(AngiotensinⅠ,AngⅠ)、血管紧张素Ⅱ(AngiotensinⅡ,AngⅡ),将所得数据进行比较并分析其与NAFLD的关系。结果:NAFLD组在未进行干预治疗前,患者血浆中RAS(PRA、AngⅠ、AngⅡ)、ALT、GGT、TG、TCHO、GLU与对照组相比较均呈升高,差异具有统计学意义(P<0.05);且RAS(PRA、AngⅠ、AngⅡ)与NAFLD的病情轻重程度呈正相关(P=0.000);NAFLD组在治疗后与治疗前相比较其RAS、ALT、GGT、TG、TCHO、GLU差异均有统计学意义(P<0.05)。结论:血浆中RAS的变化可影响NAFLD的发生发展,并能改善NAFLD患者的生化指标,有利于病情的好转。

Objective：To investigate the nonalcoholic fatty liver （ nonalcoholic fatty liver disease, non-alcoholic fatty liver disease （ NAFLD） in plasma of patients with renin angiotensin angiotensin system （ RAS） ,and the correlation was analysed. Methods：88 patients with NAFLD were randomly collected in our hospital after the clinical related blood index and liver ultrasound and other clinical diagnosed as treatment group, and 90 healthy people were selected as control group for comparison, the treatment group were treated by Valsartan Tablets intervention treatment, were detected in the plasma of patients with the ALT, GGT, TG, TCHO, GLU, PRA, Ang I, Ang II, the data are compared, and analyze its relationship with NAFLD. Results：In the treatment group without intervention, in plasma of patients with RAS （ PRA, ang Ⅰ and AngⅡ） , ALT, GGT and TG, TCHO, Glu and control group had a significantly increased （ P 〈0.05）;and RAS （ PRA, ang Ⅰand Ang Ⅱ） and NAFLD severity was positively correlated （ P = 0.000）;treatment group after treatment and be-fore treatment compared the RAS, ALT, GGT and TG, TCHO, Glu differences were statistically significant （ P 〈0.05） . Conclusion：The change of plasma RAS can affect the development of NAFLD, and can improve the biochemical index of NAFLD patients, which is conducive to the improvement of the condition.