缺血性脑血管病与S-100β、MMP-9的研究进展

Research progress of ischemic cerebrovascular disease and S-100β, MMP-9

缺血性脑血管病是中老年人的常见病、多发病，具有高致残率、高致死率、高复发率等特点，严重威胁中老年人的生命健康。目前临床上主要根据病史、神经系统症状体征及影像学检查来诊断和评估，但缺血性脑血管病发病较快，现有的诊断手段在诊断时间上存在不同程度的滞后性和局限性。相关临床研究发现，在缺血性脑血管病发病过程中伴随血清中星形细胞钙结合蛋白（S-10013）、基质金属蛋白酶-9（MMP-9）有关指标的改变。本文现就缺血性脑血管病中S-100β、MMP-9的最新进展进行综述。

Ischemic cerebrovascular disease is a common and frequently occurring disease in the elderly. It has the characteristics of high disability rate, high mortality rate, and high recurrence rate, which seriously threatens the life and health of the elderly. At present, clinical diagnosis and evaluation are mainly based on medical history, neurological symptoms and signs and imaging examination. The incidence of ischemic cerebrovascular disease is rapid, the existing diagnostic methods have different degrees of hys- teresis and limitations in the diagnosis time. Related clinical study found that in the process of ischemic ce- rebrovascular disease accompanied by serum S-100 beta, matrix metalloproteinase-9 （MMP-9）-related indi- cators of change. This article reviews the recent progress of S-100 beta and MMP-9 in isehemic cerebrovascular disease.