结直肠癌患者口服化疗药依从性与疾病感知相关性的纵向研究

Correlation between oral chemotherapy adherence and illness perception in colorectal cancer patients:a longitudinal study

目的探讨化疗不同时期结直肠癌患者口服化疗药依从性与疾病感知的相关性,以期为临床实践中提高结直肠癌患者口服化疗药依从性提供依据。方法本研究为前瞻性纵向研究,采用便利抽样的方法,运用Morisky药物依从性量表、简易版疾病感知问卷,对132例结直肠癌口服化疗患者进行问卷调查。结果化疗早期、中期、晚期患者口服化疗药依从性得分分别为(7.24±1.15)分、(6.97±1.43)分、(6.95±1.17)分,疾病感知得分分别为(40.12±9.47)分、(39.91±8.65)分、(37.01±6.83)分。化疗不同时期患者口服化疗药依从性与疾病感知均呈负相关关系(r=-0.225,P<0.05;r=-0.279,P<0.01;r=-0.277,P<0.01)。结论患者疾病感知水平越高,其依从性越差,医务人员应引导患者树立对疾病和治疗的正确认知,减小疾病对患者生活和情绪造成的不良影响,从而提高患者的口服化疗药依从性。

Objective To explore the correlation of oral chemotherapy adherence and illness perception among coloreetal cancer patients at different stages of chemotherapy in order to provide evidence for improving oral chemotherapy adherence among colorectal cancer patients in clinical practice. Methods A prospective longitudinal study was employed. Convenience sampling was used to recruit 132 cases of colorectal cancer patients. Data of general information,oral chemotherapy adherence and illness perception were collected by questionnaire. Results At different stages of chemotherapy, patient＇s score of oral chemotherapy adherence were 7.24±1.15,6.97±1.43,6.95 ± 1.17;patients＇ illness perception scores were 40.12±9.47,39.91±8.65,37.01±6.83.Oral chemotherapy adherence was negatively correlated with illness perception （r=-0.225,P〈0.05 ;r=-0.279,P〈0.01 ;r=-0.277,P〈0.01 ）. Conclusion Higher level of patient＇s illness perception was related to worse oral chemotherapy adherence. Nurses should instruct patients to understand the disease and the treatment correctly,to reduce the adverse impact on patients＇ life and emotion,and to improve patients＇ compliance with oral chemotherapy.