早产儿呼吸道分泌物解脲脲原体阳性与新生儿肺损伤的关系

Analysis of the Relationship between Premature Respiratory Secretions of Ureaplasma Urea Original Body and Neonatal Lung Injury

【目的】探讨早产儿呼吸道分泌物解脲脲原体（Uu）阳性与新生儿肺损伤的关系。【方法】选择2014年1月至2015年8月本院新生儿重症监护病房（NICU）收治的246例以呼吸道症状入院的早产儿作为研究对象，详细记录每位患儿的临床资料，入院时取胃、咽部或气道分泌物，采用荧光定量聚合酶链反应法检测Uu核酸，根据检测结果分为阳性组和阴性组；比较两组患儿的基本临床特点，感染标志物，新生儿呼吸窘迫综合征（RDS）、先天性肺炎、支气管肺发育不良（BPD）发生率及住院天数。【结果】246例早产儿中，Uu结果阳性59例，阴性187例。Uu阳性组新生儿RDS发生率显著低于阴性组；先天性肺炎、BPD发生率显著高于阴性组，差异均有统计学意义（P〈0．05）。【结论】呼吸道分泌物Uu阳性增加了早产儿先天性肺炎、BPD的发生几率，相反，其可促进胎肺的成熟，是新生儿RDS的保护性因素。

[Objective]To research the relationship between premature respiratory secretions of ureaplasma urea original body and neonatal lung injury.[Method] A total of 246 cases of premature infants with respiratory symptoms in the neonatal in tensive care unit in the Maternal and Child Health Hospital of Hunan Province from January 2014 to August 2015 were selected as the research object. The clinical data of each child was recorded in detail. According to the test results of fluorescent quami tative PCR detection of Uu nucleic acid with stomach and, pharyngeal airway secretions which were taken wheit ehey were admitted to this hospital, the patients were categorized into a positive group and a negative group. Basic clinical characteristics, infection markers, neonatal respiratory distress syndrome （RDS）, congenital pneumonia, and the incidence of bronchial pulmonary dysplasia （BPD） and the length of hospital stay of the two groups were compared.[Result] In the 246 cases of premature infants, 59 cases of Uu were positive and 187 cases of Uu were negative. In the Uu positive group, incidence of neonatal respiratory distress syndrome was 32.2% （19/59）, while in the negative group, it was 45.5% （85/187）. Incidence of congenital pneumonia in the Uu positive group was 35.6% （21/59）, while incidence in the negative group was 21.9% （46/187）. After more than 28 days in the hospital, the incidence of bronchial pulmonary dysplasia in the Uu positive group was 16.9% （10/ 59）, while incidence in the negative group was 8.02 % （15/187）. The length of hospitalization in the Uu positive group was obviously longer than in the Uu negative groups; the difference had statistical significance.[Conclusions] For preterm infants, Uu positivity in respiratory secretions increased the incidence of congenital pneumonia and bronchial pulmonary dysplasia, which extended the length of hospital stay. So, it is a protective factor of neonatal respiratory distress syndrome.