摘要
采用高温热解法制备了粒径均一的Fe_5C_2磁性纳米粒子,并在其表面包裹磷脂改善纳米粒子的水溶性和稳定性,同时在纳米粒子表面负载阿霉素(DOX)实现化疗作用.阿霉素负载的Fe_5C_2磁性纳米粒子(Fe_5C_2-DOX-DSPE-m PEG),不仅具有一定的磁学性质,且具有优良的光热转化效率.细胞实验说明该纳米粒子对肿瘤细胞具有光热治疗和化疗协同治疗作用.
In this paper,uniform sized Fe5 C2 magnetic nanoparticles were synthesized bythermaldecomposition method. The mate-rials modified with phospholipids have good solubility in water and physiological stability. Meanwhile, nanoparticles have been loaded with doxorubicin （DOX） to achieve chemotherapy. Fe2C5 -DOX-DSPE-mPEG nanoparticles havenot only magnetic proper- tiesbut high photothermal conversion efficiency. Cell experiments showed that Fe2 C5 -DSPE-mPEG loaded with DOX has a signifi-cant synergistic effect ofphotothermaltherapy and chemotherapy.
出处
《上海师范大学学报（自然科学版）》
2016年第6期729-735,共7页
Journal of Shanghai Normal University(Natural Sciences)
基金
国家自然科学基金(21571130)
关键词
Fe5C2纳米粒子
光热治疗
化疗
协同治疗
Fe5C2 magnetic nanoparticles
photothermal therapy
chemotherapy
synergistic therapeutic
