PTH、细胞内钙和CaSR在心肌损伤中的“三角关系”

Triangle relationship of PTH,intracellular calcium and CaSR in myocardial damage

甲状旁腺激素（parathyroid hormone,PTH）是甲状旁腺细胞分泌的调控机体钙磷代谢的重要激素。近年来,PTH对于心肌的毒性作用开始受到人们关注。钙敏感受体（calcium-sensing receptor,CaSR）是G蛋白偶联家族成员之一,可以感受细胞外钙浓度的细微变化,并通过多种途径调节细胞内钙浓度,进而控制PTH的分泌。CaSR在心肌细胞、

Parathyroid hormone（PTH）is an important hormone secreted by parathyroid cells,and regulates the metabolism of calcium and phosphorus in the body. In recent years,the toxic effect of PTH on myocardium has been reported. Calcium-sensing receptor（CaSR）,a member of G protein-coupled receptor family,can feel the subtle change of extracellular calcium concentration and regulate intracellular calcium concentration through multifarious ways in order to control the secretion of PTH. The expression of CaSR is observed in parathyroid cells,renal tubular epithelial cells,myocardial cells,etc. Intracellular calcium,as a second messenger,participates in various cell functions,such as excitationcontraction coupling,fertilization and so on. The injury of myocardial cells is intimately linked with high concentrations of PTH and intracellular calcium,and high expression of CaSR.