174例癌性疼痛患者使用吗啡针剂的临床观察

Clinical observation of morphine injection applied for 174 patients with cancer pain

目的:观察并评估吗啡针剂对恶性肿瘤患者缓解癌性疼痛的作用。方法:选取2013年3月22日至2015年3月26日中国医学科学院肿瘤医院综合科病房收治的癌性疼痛并使用吗啡针剂的患者174例,观察并总结其临床资料及使用吗啡针剂的疗效。结果:单原发癌共165例,双原发癌共9例。患者入院时疼痛数字评分法(NRS)评分为(5.04±2.04)分,爆发痛(1.10±1.14)次/日;住院期间55例患者死亡,其余119例患者出院时NRS评分为(1.94±1.27)分,爆发痛(0.40±0.83)次/日;入院及出院时患者NRS评分及爆发痛次数比较,差异显著(P<0.05)。患者使用吗啡针剂前NRS评分为(7.23±1.78)分,吗啡针剂30min后NRS评分为(1.43±0.82)分,差异显著(P<0.05)。结论:吗啡针剂能够显著减轻患者癌性疼痛,改善患者生活质量。

Objective：To observe and assess effect by morphine injection on relieving cancer pain in malignant tumor patients. Methods：A total of 174 patients with cancer pain at general department ward in Tumor Hospital of Chinese Academy of Medical Sciences,who received morphine injection,from March 22nd 2013 to March 26th 2015 were taken for observation and summary of medical data and curative effect by morphine injection. Results：There were 165 cases with single primary cancer and 9 cases with double primary cancer. Numeric rating scale（NRS）score of patients at admission was（5. 04 ± 2. 04）points,along with breakthrough pain by（1. 10 ± 1. 14）times/ day. There were 55 death cases during hospitalization,and the 119 discharged cases had NRS score as（1. 94 ± 1. 27）points and breakthrough pain by（0. 40 ± 0. 83）times/ day. Differences of NRS score and breakthrough pain times in patients be-tween admission and discharge had statistical significance（P 〈 0. 05）. Before administration of morphine injection,the patients had NRS score as（7. 23 ± 1. 78）points. Their score was（1. 43 ± 0. 82）points after 30 min of morphine in-jection application. Their difference had statistical significance（P 〈 0. 05）. Conclusion：Morphine injection can re-markably relieve cancer pain in patients,and improve quality of life.