肝癌干细胞的分选和治疗进展

The progress in sorting and treatment of liver cancer stem cells

肿瘤干细胞学说是目前的研究热点,多项研究表明在人类实体瘤中存在肿瘤干细胞,而干细胞数量在肿瘤细胞中含量极少,目前没有特异性肿瘤表面标志物能对肿瘤干细胞进行分选,所以如何有效分离肿瘤干细胞及干预其生长是目前值得研究的课题,本文就肝癌干细胞的表面标志物、分选方法、治疗及存在的问题做一综述。

Cancer stem cell theory is the research focus in recent years. A number of studies have shown that cancer stem cells exist in human solid tumors,while the number of stem cells in a tumor cell content is extremely low. There is no specific tumor surface markers capable of cancer stem cell sorting,so how to effectively isolated cancer stem cells and interfere with their growth is worthy of study. In this paper,liver cancer stem cell surface markers,sorting,treat-ment and problems are reviewed.