Cyclophilin B与人类肿瘤关系的最新研究进展

Recent advances of relationship between cyclophilin B and human cancer

亲环素家族(Cyps),为免疫抑制剂环孢素A(CSA)的细胞内受体,通过肽基脯氨酰顺反异构酶(PPIase)的活性和分子伴侣在细胞内发挥重要的作用。CypA在亲环素家族中首次被报道出来是其在肿瘤中呈上调表达,但是对于CypB在肿瘤中的表达尚不清楚。近年来研究发现CypB在乳腺癌、胰腺癌、肝细胞癌、胃癌及胶质母细胞瘤中表达升高,并与肿瘤细胞的生长、增殖、运动、细胞周期进程和肿瘤的形成有关。CypB可能是恶性肿瘤早期诊断潜在的生物学标志物和肿瘤治疗的靶点。现就CypB与肿瘤关系的研究进展做一综述。

Cyclophilins（Cyps）,the intracellular receptor for immunosuppressant cyclosporine A（CsA）,play an im-portant cellular role through activities of peptidyl - prolyl cis - trans isomerase（PPIase）and chaperones. Although CypA among the Cyps was first reported to be upregulated in tumors,the expression of CypB still remain unclear. Re-cent studies found that the expression of CypB upregulated in a variety of tumors including breast cancer,pancreatic cancer,hepatocellular carcinoma,gastric cancer and glioblastoma multiforme;In addition,CypB correlates closely with cell growth,cell proliferation,cell motility,cell cycle progression,and in vivo tumorigenicity capacity tumorigenesis. CypB may be is a potential biomarker for early diagnosis of malignant tumors and a potential target for the treatment. This article reviews the recent advances of relationship between CypB and cancer.