行结肠镜检查前患者单次和分次服用聚乙二醇电解质散溶液的效果观察

Effects of One-dose and Separate-doses of PEG in Bowel Preparation

目的：探讨行结肠镜检查前患者单次和分次服用聚乙二醇电解质散溶液的应用效果。方法选取行结肠镜检查患者160例，采用随机数字表法分为单次服药组（n=80）和分次服药组（n=80）。单次服药组，采用常规肠道准备方法，结肠镜检查前5 h 将3 L聚乙二醇电解质散溶液30～60 min口服完。分次服药组，结肠镜检查前10 h将1.5 L聚乙二醇电解质散溶液30～60 min口服完；结肠镜检查前5 h 再将1.5 L聚乙二醇电解质散溶液30～60 min口服完。观察比较2组患者结肠镜检查前肠道清洁度、肠道气泡情况及肠道准备不适症状。结果2组行结肠镜检查患者肠道准备评分较低，肠道清洁效果均较满意，2组患者肠道准备评分、肠道气泡情况比较差异无统计学意义（P＞0.05）；2组患者肠道准备不适症状中恶心、腹痛、肛门刺激、失眠及饥饿平均秩次比较差异有统计学意义（P＜0.05）。结论单次和分次服用聚乙二醇电解质散溶液肠道清洁效果相当，但分次服药肠道准备不适症状较轻，值得临床借鉴使用。

Objective To discuss different effects of one-dose and separate-doses of PEG in bowel preparation. Methods Totally 160 patients were enrolled and randomized into one-dose group （n=80） and separate-dose group （n=80） to evaluate bowel preparation quality. One-dose group took 3L PEG orally in 30-60 min 5 h before colonoscopy examination and separate-dose group took 3L PEG separately 10 h and 5 h before the examination. Quality of cleansing, the existing of air bubbles and side effects during the bowel preparation were assessed. Results The scores of bowel preparation were lower in 2 groups , the PEG cleaning quality in 2 groups were satisfied. The scores of bowel preparation and existing of air bubbles of 2 groups had no statistical significance （ P〉0.05）, but nausea, abdominal pain, anal stimulation, insomnia and hunger had statistical significance （ P〈0.05）. Conclusion Even though one-dose and separate-dose of PEG have effective cleaning effect before the colonoscopy, there are slighter side effects with the latter.