2014年老年病房内铜绿假单胞菌感染状况及其耐药性分析

Analysis of infection situation and drug resistance of Pseudomonas aeruginosa isolated from Department of Geriatrics in 2014

目的分析老年病房内铜绿假单胞菌的感染状况及耐药情况。方法收集2014年1-12月安徽省立医院老年内分泌科临床感染患者的痰、尿或血标本,采用法国梅里埃公司的VITEK2 Compact进行细菌鉴定及药敏实验。结果共检出63株细菌,其中铜绿假单胞菌共29株,占46.03%。29株铜绿假单胞菌中,痰培养阳性26株（89.66%）,尿培养阳性3株（10.34%）。多重耐药的铜绿假单胞菌16株,占55.17%,耐药率低于10%的药物有阿米卡星、庆大霉素和妥布霉素,耐药率超过80%的有哌拉西林、头孢唑林、头孢曲松、头孢替坦、复方新诺明和呋喃妥因,对亚胺培南的耐药率为13.79%。结论老年患者是铜绿假单胞菌的易感人群,临床多表现为肺部感染,细菌耐药率高。

Objective To investigate theinfection situation and drug resistance of Pseudomonas aeruginosa in Department of Geriatricsin a hospital. Methods Sputum,urine,and blood samples were collected during the year of 2014. The bacteria identification and drug sensitivity analysis were done by using VITEK 2 compact. Results There were 29 Pseudomonas aeruginosa cases from sputum and urine samples detected in 63 bacteria cases with the detecting rate of 46. 03%; 26（89. 66%） cases were from sputum samples whereas 3（10. 34%） cases were from urine. Among all detected Pseudomonas aeruginosa cases,16（55. 17%） of them were multi-resistant. Drugs with resistance rate less than 10% were Amikacin,gentamicin and tobramycin; drugs with resistance rate higher than 80% were piperacillin,cefazolin,ceftriaxone,cefotetan,cotrimoxazole,and nitrofurantoin,and the resistance rate of imipenem was 13. 79%. Conclusion Elderly patients are susceptible to Pseudomonas aeruginosa infection with clinical manifestation of pneumonia anda high rate of antibiotics resistance.