紫杉醇脂质体或紫杉醇注射液联合顺铂治疗宫颈癌的疗效与安全性差异的临床观察

Clinical Observation of Curative Effect and Safety Differences of Paclitaxel Liposome or Paclitaxel Injection Combined with Cisplatin Treatment for Cervical Cancer

目的比较紫杉醇脂质体或紫杉醇注射液联合顺铂治疗中晚期宫颈癌的临床效果与安全性差异。方法选取2009年6月~2010年6月在我院诊治的中晚期宫颈癌患者83例,随机分为观察组42例和对照组41例,观察组第1天给予紫杉醇脂质体135 mg·m-2静脉滴注,第2天给予顺铂60 mg·m-2静脉滴注;对照组第1天给予紫杉醇注射液135 mg·m-2静脉滴注,第2天给予顺铂60 mg·m-2静脉滴注。两组患者皆采取同步放化疗方案,比较两组患者治疗宫颈癌的临床效果（近期疗效和远期疗效）及安全性差异。结果观察组治疗宫颈癌的有效缓解率为83.33%,对照组为68.29%,差异有统计学意义（P〈0.05）;观察组的宫颈癌旁浸润和淋巴结转移显著低于对照组,5年生存率显著高于对照组（P〈0.05）;观察组在脱发、胃肠道反应、过敏反应、骨髓抑制及免疫力下降等不良反应方面与对照组相比存在显著安全性差异（P〈0.05）。结论紫杉醇脂质体联合顺铂治疗宫颈癌的近期疗效和远期疗效良好,且安全性相对较高。

Objective To observe the clinical effect and safety differences of paclitaxel liposome or paclitaxel injection combined with cisplatin in patients with middle and advanced cervical cancer. Methods 83 cases of patients with middle and advanced cervical cancer from June 2009 to June 2010 in our hospital were enrolled as study subjects and randomly divided into two groups, 42 cases in observation group and 41 cases in control group. Observation group was given paclitaxel liposome 135 mg·m-2 via intravenous drip on the first day, cisplatin 60 mg·m-2 was given via intravenous drip on the second day; control group was given paclitaxel injection 135 mg·m-2 via intravenous drip on the first day, cisplatin 60 mg·m-2 was given via intravenous drip on the second day. The two groups all took concurrent radiochemotherapy scheme. The clinical effect（recent curative effect and the forward curative effect） and safety differences between two groups in the treatment of cervical cancer were compared. Results The effective alleviation rates of observation group and control group were 83.33% and 68.29% respectively, the difference was statistically significant（P0.05）. The cervical cancer invasion and lymph node metastasis of observation group was significantly lower than control group, and the 5-year survival rate of the observation group was significantly higher than the control group（P0.05）. The adverse drug reaction such as alopecia, gastrointestinal reaction, anaphylactic reaction, myelosuppression and weakened immunity in observation group has significant differences compared with the control group（P0.05）. Conclusion In this study, paclitaxel liposome combined with cisplatin has good recent curative effect and forward curative effect and safety is relatively high in the treatment of cervical cancer.