益气通脉汤对冠心病心绞痛病人机体Gal-3,ESM-1和Omentin-1水平的影响

Impact of Yiqi Tongmai Decoction on Gal-3,ESM-1 and Omentin-1 in Patients with Angina Pectoris

目的观察益气通脉汤联合西药治疗冠心病的疗效及对心功能、血液黏度、半乳糖凝集素-3（Gal-3）、内皮细胞特异分子（ESM）-1和人网膜素（Omentin）-1水平的影响。方法选择2010年1月—2014年12月冠心病心绞痛病人86例,随机分为观察组和对照组,每组43例。对照组予以常规治疗,观察组在对照组治疗基础上予以益气通脉汤治疗。观察两组治疗后疗效,及其白细胞比容治疗前后左室射血分数（LVEF）、6 min步行试验（6MWT）、N末端脑钠肽原（NT-pro BNP）、血液黏度、红细胞聚集指数、血细胞比容,Gal-3、ESM-1和Omentin-1水平的变化。结果观察组总有效率为95.35%,明显高于对照组76.74%,两组比较差异有统计学意义（χ^2=4.746,P〈0.05）。两组治疗前LVEF、6MWT、NT-pro BNP、血液黏度、红细胞聚集指数、血细胞比容、Gal-3、ESM-1和Omentin-1水平比较,差异无统计学意义（P〉0.05）;两组治疗后LVEF、6MWT和Omentin-1水平较治疗前明显升高,NT-pro BNP、血液黏度、红细胞聚集指数、血细胞比容、Gal-3、ESM-1水平较治疗前明显降低,而观察组升高或降低水平更明显,差异有统计学意义（P〈0.01）。结论益气通脉汤能提高治疗冠心病的疗效,可增强心功能,降低血液黏度,改善血管内皮功能,抑制炎症因子释放。

Objective To observe the efficacy of Yiqi Tongmai decoction（ YTD） combined with western medicine,and their impact on the levels of heart function,blood viscosity,galectin-3（ Gal-3）,endothelial cell-specific molecule（ ESM）-1 and human Omentin（ Omentin）-1.Methods Eighty-six patients with angina pectoris,from January 2010 to December 2014,were randomly divided into two groups： control group（n = 43） treated with conventional treatment,and observation group（n = 43） treated with YTD plus conventional treatment. Efficacy after treatment,the levels of left ventricular ejection fraction（ LVEF）,6 min walk test（ 6MWT）,N-terminal brain natriuretic peptide（ NTpro BNP）,plasma viscosity,erythrocyte aggregation index,hematocrit,Gal-3,ESM-1 and Omentin-1 before and after treatment were observed in each groups. Results The total effective rate was 95. 35% in observation group significantly higher than 76. 74% in control group（ χ^2=4. 746,P〈0.05）. Before treatment,the levels of LVEF,6MWT,NT-pro BNP,plasma viscosity,erythrocyte aggregation index,hematocrit,Gal-3,ESM-1 and Omentin-1 had no significant difference between two groups（P〉0.05）. After treatment,the levels of LVEF and 6MWT were significantly higher in two groups than those before treatment,the levels of NT-pro BNP,plasma viscosity,erythrocyte aggregation index,hematocrit,Gal-3,ESM-1 and Omentin-1 in two groups decreased compared with those before treatment,and the elevated or decreased levels were significantly more obvious in observation group（P〈0.01）. Conclusion YTD can improve the efficacy of western medicine in patients with angina pectoris,enhance cardiac function,reduce blood viscosity,improve endothelial function,and inhibit the release of inflammatory cytokines.