造血生长因子治疗再生障碍性贫血合并肺部感染的疗效及对T淋巴细胞亚群的影响

Efficacy of Haematopoietic Growth Factors on Aplastic Anemia Combined with Pulmonary Infection and Effects on T Lymphocyte Subsets

目的探究造血生长因子治疗再生障碍性贫血合并肺部感染的疗效及对T淋巴细胞亚群的影响。方法以2014年1月至2016年7月我院接诊的再生障碍性贫血合并肺部感染患者114例作为研究对象，随机分为两组，每组各57例。对照组予以免疫抑制治疗，观察组在此基础上加用造血生长因子。比较两组疗效及T淋巴细胞亚群水平。结果治疗后，观察组的治疗总有效率、T淋巴细胞亚群指标、临床症状缓解时间优于对照组，差异显著（P〈0．05）。结论采用造血生长因子治疗再生障碍性贫血合并肺部感染的疗效确切，对改善患者的T淋巴细胞免疫力、加速其康复进程均具有积极意义。

Objective To investigate the efficacy of haematopoietic growth factors （HGF） in the treatment of aplastic anemia（AA） combined with pulmonary infection and its effects on T lymphocyte subsets. Methods 1 ld pa- tients with AA combined with pulmonary infection from Jan. 2014 to Jul. 2016 were randomly divided into two groups with 57 patients in each group. Immunosupressive therapy was used in control group and HGF was added in observa- tion group. The efficacy and T lymphocyte subsets levels of two groups were compared. Results Total effective rate, T lymphocyte subsets indexes and relief time of clinical symptoms after treatment in observation group were better than those in control group（P 〈 0.05）. Conclusion HGF has a definite efficacy for treating AA combined with pulmonary infection, which can improve T lymphocyte immunity and accelerate recovery process.