聚卟啉咪唑药物载体的制备及性能研究

Synthesis and properties of porphyrin-imidazole polymer as drug carrier

药物传递体能够起到药物缓释、提高药物生物利用率、降低药物高浓度带来副作用的功效。制备了粒径80 nm以下的卟啉聚合物药物载体,利用红外光谱(IR)、X-射线粉末衍射(XRD)确定了聚合物的结构,利用扫描电子显微镜(SEM)确定了材料的形貌和粒径,并利用N_2和CO_2吸附测试确定了材料的比表面积和孔径大小,表明材料具有良好的孔结构。进而对该材料装载和释放抗癌药物5-氟尿嘧啶性能进行了研究。

Drug delivery system can play a key role on including a drug slow release, improving drug bioavailability, reducing the high concentration of drugs and other side effects. A polyporphyrin drug carrier with a two - dimensional structure of less than 80 nm was prepared. The structure of the polymer was characterize by IR and XRD. The morphology and particle size were determined by scanning electron microscopy （SEM）. The adsorption capacity, specific surface area and pore size of the material were determined by N2 and CO2adsorption to be tested, which indicated that the material had good pore structure. Loading and release of 5 -fluorouracil experiments showed that the drug delivery body could be loaded with drugs, and controlled time for drug release.