百乐眠口服结合物理刺激治疗肝郁阴虚型不寐的有效性与安全性分析

The Effectiveness and Safety of Bailemian Oral combined with Physical Stimulation Therapy in the Treatment of Liver Deficiency Type Insomnia

目的研究观察百乐眠口服结合物理刺激治疗肝郁阴虚型不寐的有效性与安全性。方法2011年8月到2016年1月选择在朝阳区左家庄社区卫生服务中心诊治的肝郁阴虚型不寐患者96例,根据入院顺序分为实验组与对照组各48例,对照组给予综合物理刺激治疗,在此基础上实验组给予百乐眠胶囊治疗。结果治疗后实验组的有效率明显高于对照组(P<0.05)。实验组与对照组治疗后的睡眠质量评分都明显低于治疗前,组内与组间对比差异明显(P<0.05)。实验组治疗后的CD^(3+)值明显上升,而CD^(4+)值明显降低,组内与组间对比差异明显(P<0.05)。结论百乐眠口服结合物理刺激治疗肝郁阴虚型不寐能改善患者的睡眠质量,提高治疗疗效,且安全性较好,其作用机制可能与改善患者的T淋巴细胞亚群免疫水平有关。

Objective To evaluate the effectiveness and safety of Bailemian oral combined with physical stimulation therapy in the treatment of liver deficiency type insomnia. Methods From August 2011 to January 2016,96 liver deficiency type insomnia patients in Zuojiazhuang community health service center were selected. All patients were equally divided into experimental group and control group of 48 patients, the control group was given comprehensive physical stimulation treatment, on the basis of the experimental group were give Bailemian capsule for treating. Results The effective rate of the experimental group was significantly higher than that of the control group （P 〈 0.05）, and the two groups had no serious adverse reactions during the treatment period. The sleep quality scores of the experimental group and the control group after treatment were significantly lower than before treatment （P 〈0.05）. The CD3^＋ value were significantly increased, while the CD4^＋ value were significantly decreased in the two groups and compared the difference between the groups was significant （P〈0.05）. Conclusion Bailemian oral combined with physical stimulation therapy in the treatment of liver deficiency type insomnia can improve the sleep quality of patients and improve the therapeutic efficacy and its safety is better, its mechanism may related with the improvement of patients with T lymphocyte subsets in immunity.