大剂量洛赛克联合生长抑素治疗消化性溃疡出血的临床研究

Clinical study of high-dose losec combined with somatostatin treatment for peptic ulcer hemorrhage

目的研究大剂量洛赛克(注射用奥美拉唑钠)联合生长抑素治疗消化性溃疡出血的临床效果。方法纳入我院收治的消化性溃疡出血患者86例,随机分为两组,各43例。其中43例患者采用生长抑素进行治疗作为对照组,另43例患者在上述基础上联合大剂量注射用奥美拉唑钠治疗作为观察组。观察两组治疗效果、临床症状以及不良反应情况。结果对照组、观察组总有效率分别为86.05%、97.67%,观察组明显较高(P<0.05)。观察组止血时间、住院时间以及VAS评分均明显优于对照组(P<0.05)。对照组、观察组不良反应发生率分别为13.95%、11.63%,两组对比无明显差异(P>0.05)。结论生长抑素联合大剂量注射用奥美拉唑钠治疗消化性溃疡出血患者具有止血快、疗效好、不良反应低等优势,值得临床应用及推广。

Objective To investigate the clinical effect of high-dose losec（omeprazole sodium for injection） combined with somatostatin in the treatment of peptic ulcer hemorrhage. Methods 86 cases of peptic ulcer bleeding were admitted from August 2012 to August 2015 in our hospital, who were divided into two groups equally according to the random number table. One group was treated with somatostatin as the control group, while the other group was treated with high-dose losec additionally as the observation group. To observe the therapeutic effect, clinical symptoms and adverse reactions of the two groups. Results The total effective rate of the control group and observation group was 86.05% and 97.67% respectively, the observation group was significantly higher（P〈0.05）. The hemostatic time, hospital stays and VAS score of the observation group were significantly better than those of the control group（P〈0.05）. The incidence of adverse reactions in the control group and observation group were 13.95% and 11.63% respectively, with no significant difference between the two groups（P〉0.05）. Conclusion Somatostatin combined with high-dose losec in the treatment of peptic ulcer bleeding had advantages of hemostasis, therapeutic effect, and less adverse reaction,which was worthy of clinical application and promotion.