摘要
1.The identification ofβ-secretase asβ-site amyloid precursor protein cleaving enzyme（BACE）Following the discoveries ofβ-amyloid（Aβ）and the firs amyloid precursor protein（APP）mutations that cause familial Alzheimer’s disease（AD）,it soon became clear that theβ-andγ-secretase enzymes were prime therapeutic targets for the development of small-molecule inhibitor drugs for the treatment of AD.
1.The identification ofβ-secretase asβ-site amyloid precursor protein cleaving enzyme(BACE)Following the discoveries ofβ-amyloid(Aβ)and the firs amyloid precursor protein(APP)mutations that cause familial Alzheimer’s disease(AD),it soon became clear that theβ-andγ-secretase enzymes were prime therapeutic targets for the development of small-molecule inhibitor drugs for the treatment of AD.Thus,their molecular identities were
