β-环糊精和水杨醛缩邻硝基苯胺包合行为的紫外-可见光谱研究

Study on UV-Vis Spectra of Clathration Behavior of β-cyclodextrin and Salicylaldehyde-2-nitroaniline

用固相研磨法合成以β-环糊精(β-CD)为主体分子,水杨醛缩邻硝基苯胺(SN)为客体分子的包合物.用红外光谱和紫外-可见分光光度法分析包合物的形成,并用等摩尔系列法和元素分析求得包合比为3∶2的包合物,包合平衡常数Ka=6.28×1015 L4/mol 4.结果表明,包合后的SN分子在水中的溶解度增加1倍,而且稳定性也增加,达到提高生物利用度的目的.比较其他结构相似的水杨醛类化合物的包合数据,β-CD有能力识别同系客体在结构上的细微变化.

The inclusion complex ofβ-cyclodextrin（β-CD-the host molecule）and salicylaldehyde-2-nitroaniline（SN-the guest molecule）was synthesized with solid state grinding method.The forming of clathrate compound was under analysis with infrared spectroscopy and UV-Vis,the clathrate compound with host/guest molecule rate 3：2 was obtained with equimolar series method and elemental analysis,including equilibrium constant Ka=6.28×1015L4/mol 4.The result shows that,SN molecule’s solubility in water will double after clathration,and the stability will increase to enhance the bioavailability.Comparing with the other clathration data of salicylaldehyde compound with similar structure,β-CD is capable of recognizing the subtle variation in guest molecules in structure.