QT间期缩短与变异型心绞痛室性心律失常

Shorter QT interval and ventricular arrhythmias in variant angina

目的:分析变异型心绞痛发作时QT间期缩短与室性心律失常之间的相关性。方法:纳入我院变异型心绞痛患者共86例,收集每例患者24h动态心电图资料、变异型心绞痛发作时和不发作时的12导联心电图,计算发作时和不发作时的校正QT间期,与不发作时的校正QT间期对比,发作时的校正QT间期缩短的患者列入QT缩短组,其余患者列入对照组,并随访1年,对比两组在年龄、性别、吸烟比例、高敏C反应蛋白水平、高血压比例、糖尿病比例、血脂紊乱比例、冠脉病变比例的差异,对比两组在室性期前收缩负荷、室性心动过速发生比例、晕厥或猝死发生比例的差异。结果:QT缩短组吸烟比例、高敏C反应蛋白水平高于对照组,室性期前收缩负荷、室性心动过速发生比例亦高于对照组,差异均有统计学意义(P<0.05),年龄、性别、高血压比例、糖尿病比例、血脂紊乱比例、冠状动脉病变比例与对照组无统计学差异(P>0.05),晕厥或猝死发生比例与对照组无统计学差异(P>0.05)。QT缩短组有1例患者合并继发性短QT间期综合征,并发生猝死。结论:变异型心绞痛发作时QT间期缩短与患者室性心律失常的发生存在正相关。

Objective：To analysis correlation between shorter QT interval in the episode stage of angina than the remission stage and ventricular arrhythmias.Method：The 86 patients with variant angina were selected.The 24-hour ambulatory electrocardiogram and 12-lead electrocardiograms in both episode and remission stages of angina were collected.The corrected QT（QTc）interval was calculated.All patients were collected the load of premature ventricular contraction,the incidence of ventricular tachycardia,and incidence of syncope or sudden death.Result：The proportion of patients smoking,the concentration of high-sensitivity C-reactive protein,the load of premature ventricular contraction,the proportion of patients with ventricular tachycardia,were higher in the group of shorter QT than in the control group（P〈0.05）.There was no significant difference in other indexes（P〉0.05）.There was only one patient complicated with required short QT interval syndrome in the group of shorter QT who suffered from sudden death.Conclusion：Shorter QT interval has positive correlation with ventricular arrhythmias in variant angina.