儿童哮喘急性发作期血清25-羟基维生素D、总IgE水平变化及临床意义

The levels of serum 25-hydroxy vitamin D, total IgE of children with asthma acute attack and their clinical significance

目的探讨儿童哮喘急性发作期血清25-羟基维生素D、总IgE水平变化及与疾病严重程度的关相关性。方法选取2014年6月至2015年12月本院儿科门急诊及住院的66例哮喘患儿以及30例同期健康幼儿为研究对象，分别采用电化学发光法及免疫放射分析法测定其血清25-羟基维生素D及血清总IgE水平。结果三组哮喘急性发作期不同患病程度的哮喘患儿血清25-羟基维生素D水平较对照组均降低，而血清总IgE水平均升高，差异有统计学意义（P〈0．05）；且随着疾病进程，其血清25-羟基维生素D水平降低而总IgE水平增高。相关性分析结果表明，缓解组及轻度组患儿血清25-羟基维生素D与血清总IgE水平不相关（r=0．207，P=0．112；r=0．127，P=0．251）；中重度患儿血清25-羟基维生素D与血清总IgE水平呈现负相关（r=-0．698，P〈0．05）。结论哮喘患儿血清25-羟基维生素D及总IgE参与哮喘急性发作进程，且两者呈现负相关，提示25-羟基维生素D对IgE有抑制作用。

Objective To explore the relationship between serum 25-hydroxy vitamin D, total IgE levels and the severity of asthma acute attack in children. Methods The serum of 98 asthmatic children and 30 healthy children were recruited from out-patient and emergency departments of pediatrics of our hospital from June 2014 to December 2015. Detected serum 25-（OH）D3 level with the electrochemical luminescence method, detected serum total IgE level with immune radiometric analysis. Results Compared to the control, serum 25-hydroxy vitamin D level decreased but serum total IgE level increased in asthma children with different degree of disease （P〈0.05）. As the process of the disease, serum 25-hydroxy vitamin D level reduced and serum total IgE level increased. The correlation analysis results showed that serum 25-hydroxy vitamin D and total IgE levels were not relevant in remission group and mild group （r=0.207, P=0.112; r=0.127, P=0.251）, there was negative correlation between serum 25-hydroxy vitamin D and total IgE levels in moderate to severe children （r= - 0.698, P〈0.05）. Conclusion Serum 25-hydroxy vitamin D, total IgE levels are closely correlated with the severity of asthma acute attack in children, which provides the basis for vitamin D in the prevention of asthma in children.