普拉克索联合高压氧舱治疗帕金森病伴睡眠障碍患者的疗效观察

Curative effect observation of pramipexole in combination with hyperbaric oxygen therapy in Parkinson＇s disease patients with dyssomnia

目的探讨普拉克索联合高压氧舱治疗帕金森病合并睡眠障碍的临床疗效。方法选取80例合并睡眠障碍的帕金森病患者，根据治疗方法的不同分为3组。普拉克索组25例，给予口服盐酸普拉克索治疗；高压氧组25例，给予高压氧舱吸氧治疗；联合组30例，给予VI服盐酸普拉克索联合高压氧舱吸氧治疗。3组患者均接受为期2个月的治疗，观察并记录患者治疗前后睡眠质量水平及焦虑抑郁程度的差异。结果治疗后，联合组患者PQSI评分、ESS评分分别为（4．36±1．22）、（2．19±3．52），均明显低于普拉克索组[（6．88±1．83）、（5．62±4．33）]和高压氧组[（6．54±1．66）、（5．16±3．96）]，组间比较差异有统计学意义（P〈0．05）；联合组患者UPDRS-Ⅲ评分、H=Y分级评分低于普拉克索组和高压氧组，但组间比较差异无统计学意义（P〉0．05）；联合组卧床时间、总睡眠时间、睡眠效率明显高于普拉克索组和高压氧舱组（P〈0．05），睡眠潜伏期和睡眠觉醒次数明显低于普拉克索组和高压氧舱组（P〈0．05）。3组患者临床不良反应发生率比较差异无统计学意义（P〉0．05）。结论普拉克索联合高压氧舱治疗帕金森病伴睡眠障碍患者临床疗效显著，能够有效提高睡眠效率，改善睡眠质量，值得临床推广。

Objective To investigate curative effect of pramipexole in combination with hyperbaric oxygen therapy in Parkinson＇s disease patients with dyssomnia. Methods 80 Parkinson＇s disease patients with dyssomnia were randomly divided into three groups according to the therapy. Pramipexole group （25 cases） was treated with oral pramipexole, hyperbaric oxygen group （25 cases） was treated with hyperbaric oxygen therapy, combination group （30 eases） was treated with oral pramipexole combined with hyperbaric oxygen therapy. All patients were treated for 2 months, compared the sleep quality, the degree of anxiety and depression before and after treatment. Results After treatment, PQSI score and ESS score of combination group were （4.36±1.22） and （2.19±3.52）, significantly lower than those of pramipexole group [（6.88±1.83）, （5.62±4.33）] and hyperbaric oxygen group [（6.54＋1.66）, （5.16±3.96）], with statistically significant differences among three groups （P〈0.05）. UPDRS- Ⅲ score and H-Y score of combination group were lower than those of pramipexole group and hyperbaric oxygen group, without statistically significant differences among three groups （P〉0.05）. The time in bed, total sleep time, sleep efficiency of combination group were significantly higher than those of pramipexole group and hyperbaric oxygen group （P〈0.05）, the sleep latency and the times of arousal were significantly lower than those of pramipexole group and hyperbaric oxygen group （P〈0.05）. Conclusion Pramipexole combined with hyperbaric oxygen therapy has significant effect in Parkinson＇s disease patients with dyssomnia, which can effectively improve sleep eff^ciency and sleep quality, worthy of clinical promotion.