胰岛素联合六味地黄丸对老年早期糖尿病肾病患者血清Hcy、Cys-C水平的影响及临床疗效的研究

Influence and clinical effects of insulin combined with pills of six ingredients with rehmannia on serum Hcy and Cys-C levels among aged sufferers with early diabetic nephropathy

目的探讨胰岛素联合六味地黄丸对老年早期糖尿病肾病患者血清同型半胱氨酸(Hcy)、胱抑素C(Cys-C)水平及临床疗效的影响。方法收集沈阳市第七人民医院收治的早期糖尿病肾病患者100例,随机分为对照组和实验组,每组各50例,对照组患者根据血糖情况给予胰岛素,1~2次/d,实验组患者在此基础上给予六味地黄丸,1丸/次,2次/d,口服。连续4周。治疗结束后,对患者糖化血红蛋白(Hb A1c)、Hcy、Cys-C及临床疗效进行检测并比较。结果与治疗前相比,两组患者的Hb A1c、Hcy、Cys-C均下降(P<0.05);与对照组相比,实验组患者Hb A1c、Hcy、Cys-C水平较低(P<0.05),实验组患者治疗总有效率较高(P<0.05)。结论胰岛素联合六味地黄丸能够降低老年早期糖尿病肾病患者血清Hb A1c、Hcy、Cys-C水平,临床疗效较好。

Objective To investigate the influence of insulin combined with pills of six ingredients with rehmannia on serum Hcy and Cys-C levels and clinical effects among aged sufferers with early diabetic nephropathy.Methods 100 cases with early diabetic nephropathy admitted to Shenyang No.7 People＇s Hospital were selected and randomly divided into experiment group and control group with 50 cases in each group.The control group were treated by insulin 1 ~ 2 times a day according to blood glucose status, while the experiment group were given of pills of six ingredients with rehmannia for one pill a time and twice a day on the basis of the control group, orally taken for 4 consecutive weeks.The levels of HbAlc ,Hcy, and Cys-C and clinical effects were detected and compared after treatment.Results Compared with those before treatment,the levels of HbAlc ,Hcy, and Cys-C were decreased in both groups （P 〈 0.05）;Compared with those of the control group, the levels of HbAlc, Hcy, and Cys-C levels of the experiment group were lower（P〈0.05）, and the total effective rate of the experiment group was higher（P〈0.05）.Conclusion Insulin combined with pills of six ingredients with rehmannia can reduce the levels of HbA1c, Hcy, and Cys-C among aged sufferers with early diabetic nephropathy, with good clinical effects.