乌骨藤片在急性髓系白血病治疗中的应用

Effect of Wuguteng tablets in the treatment of acute myeloid leukemia

目的:观察乌骨藤片在急性髓系白血病(AML)治疗中的应用效果。方法:对2015年3月~2016年1月间昆明医科大学第一附属医院收治的病历资料完整的AML患者60例进行分析,入选患者依据治疗方案不同分为研究组及对照组,各30例,两组入院均给予常规化疗方案治疗,研究组在常规化疗的基础上加服乌骨藤片治疗,对比两组治疗前及治疗2个月后ECOG值、血常规及平均输血间隔等数据,以判定治疗效果。结果:两组治疗后白细胞计数(WBC)、血红蛋白(Hb)计数比较无统计学差异(P<0.05),研究组治疗后血小板(PLT)计数明显高于对照组(P<0.05);研究组治疗后ECOG、红细胞(RBC)平均输注间隔与治疗前比较无统计学差异(P>0.05),PLT平均输注间隔较治疗前明显延长(P<0.05);对照组治疗后ECOG较治疗前明显升高(P<0.05),PLT平均输注间隔较治疗前明显缩短(P<0.05);研究组治疗后ECOG明显低于对照组(P<0.05),PLT平均输注间隔较对照组明显延长(P<0.05)。结论:乌骨藤辅助治疗AML,可明显延长AML患者PLT平均输注间隔,升高PLT,改善患者临床症状,值得临床推广应用。

Objective： To observe the application effect of Wuguteng tablets in the treatment of acute myeloid leukemia（ AML）. Methods： A total of 60 patients with AML who were admitted in The First Affiliated Hospital of Kunming Medical University from March,2015 to January,2016 were included in the study and divided into the study group and the control group with 30 cases in each group according to different treatment protocols. The patients in the two groups were given routine chemotherapy regimens. On this basis,the patients in the study group were given additional Wuguteng tablets. ECOG value,blood routine examination results,and average transfusion interval before treatment and 2 months after treatment in the two groups were compared in order to estimate the therapeutic effect. Results： The comparison of WBC and Hb count after treatment between the two groups was not statistically significant（ P〉0. 05）. PLT count after treatment in the study group was significantly higher than that in the control group（ P〈0. 05）. ECOG and RBC average transfusion interval after treatment in the study group were not significantly different from those before treatment（ P〉0. 05）,while PLT average transfusion interval was significantly delayed when compared with before treatment（ P〈0. 05）. ECOG after treatment in the study group was significantly elevated（ P〈0. 05）,while PLT average transfusion interval was significantly reduced when compared with before treatment（ P〈0. 05）. ECOG after treatment in the study group was significantly lower than that in the control group（ P〈0. 05）,while PLT average transfusion interval was significantly delayed when compared with the control group（ P〈0.05）. Conclusions： Wuguteng tablets in the adjuvant treatment of AML can significantly delay PLT average transfusion interval,increase PLT,and improve the clinical symptoms; therefore,it deserves to be widely recommended in the clinic.