孟鲁司特联合延伸护理在小儿支气管哮喘患儿中的应用分析

Analysis of montelukast in combined with extended care applied in children with bronchial asthma

目的:探讨孟鲁司特联合延伸护理在小儿支气管哮喘治疗中的应用效果。方法:选取2014年5月~2015年5月在我院接受治疗的80例支气管哮喘患儿为研究对象,随机分为观察组和对照组,各40例,两组患儿入院均给予常规处置,并给予匹多莫德颗粒口服;观察组在常规治疗的基础上加服孟鲁司特,并于出院后进行延伸护理,采集两组治疗前及治疗3个月后后空腹外周静脉血,免疫比浊法测定血清IgA、IgG、IgM;使用肺功能仪测定第1秒用力呼气末容积(FEV_1)、用力肺活量(FVC)、呼气峰流速(PEF);并对患儿出院1年内哮喘发作次数、再入院率、再急救率、急救次数进行回访、记录。结果:两组治疗后IgA、IgG升高(P<0.05),Ig M无明显变化(P>0.05),观察组IgA、IgG升高程度大于对照组(P<0.05);两组治疗后FEV_1(L)、FVC(L)、PEF(L/min)升高,与同组治疗前比较差异显著(P<0.05),观察组FEV_1、FVC、PEF升高程度大于对照组(P<0.05);观察组随访1年哮喘发作次数、再入院率、再急救率、急救次数低于对照组(P<0.05)。结论:在常规治疗的基础上加用孟鲁司特,能更为有效控制患儿哮喘症状,改善肺功能;患儿出院后进行延伸护理,更有利于患儿哮喘发作控制,提高其生活质量。

Objective： To explore the application effect of montelukast in combined with extended care in children with bronchial asthma. Methods： A total of 80 children with bronchial asthma who were admitted in our hospital from May,2014 to May,2015 were included in the study and randomized into the observation group and the control group with 40 cases in each group. The patients in the two groups were given routine treatments and pidotimod granules. On this basis,the patients in the observation group were given additional montelukast and extended care after discharge. The fasting peripheral venous blood before treatment and 3 months after treatment in the two groups was collected. The immunoturbidimetry was used to detect the serum IgA,IgG,and IgM. The pulmonary function detector was used to detect FEV1,FVC,and PEF. Follow-up visits were paid to record the asthma attack times,readmission rate,re-first aid rate,and first aid times after discharge within 1 year. Results： IgA and IgG after treatment in the two groups were significantly elevated（ P〈0. 05）,while Ig M had no significant change（ P〉0. 05）. The elevated degree of IgA and IgG in the observation group was significantly greater than that in the control group（ P〈0. 05）. FEV1（ L）,FVC（ L）,and PEF（ L/min） after treatment in the two groups were significantly elevated when compared with before treatment（ P〈0. 05）. The elevated degree of FEV1,FVC,and PEF in the observation group was significantly greater than that in the control group（ P〈0. 05）. The asthma attack times,readmission rate,re-first aid rate,and first aid times after discharge within 1 year in the observation group were significantly lower than those in the control group（ P〈0. 05）. Conclusions： The routine treatment in combined with montelukast can better effectively control the symptoms in children with asthma,and improve the pulmonary function. After discharge,the extended care can be more beneficial to control the asthma attack,and enhance the living quality.