多粘菌素耐药性的研究进展

Progress in drug resistance of polymyxin

多粘菌素因在多重耐药革兰氏阴性菌上的治疗效果良好,再度被应用于临床,其耐药水平在多种抗菌药中曾一度较低,但目前有研究表明多粘菌素的耐药率有增加趋势。作为抗击多重耐药革兰氏阴性菌的最后一道防线,如何抑制其耐药的发生就显得尤为重要。本文就多粘菌素的耐药性现状、产生机制及防控措施三个方面进行了综述,为指导临床科学合理使用多粘菌素及革兰氏阴性菌耐药菌株传播和蔓延的防控措施提供理论依据。

Because of its effectiveness in curing infections caused by multi-drug resistant Gram-negative bacteria, polymyxin is applied to clinic again. Its drug resistance is generally low among a variety of antibiotics. However, there are studies showing that the drug resistance of polymyxin increases. As the last resort for treating multi-drug resistant Gram-negative bacteria, the occurrence of polymyxin resistance is especially important. This article summarizes the present situation, the underlying mechanism and the counteracting measure for polymyxin resistance so as to provide guidance for scientific and rational use of polymyxin in clinic, for controlling and reducing the dosage of polymyxin and for the measures in the prevention of spread and pervasion of polymyxin resistant Gram-negative bacteria.