Ghrelin对先天性心脏病患儿生长发育和心脏功能的影响及意义

The influence and significances of ghrelin on growth and cardiac function in infants with congenital heart disease

生长激素释放肽(ghrelin)是生长激素(GH)释放激素受体的内源性配体,可调节GH分泌、刺激食欲、调节能量代谢、改善心血管功能。先天性心脏病(CHD)患儿常常存在营养不良、生长发育迟缓,这与能量摄入不足、吸收差,而需要量增加、解剖及血流动力学的改变有关。多数CHD患儿在婴幼儿期就逐渐出现心功能不全以及生长发育受限,从而出现严重的并发症。Ghrelin对早期发现潜在的CHD患儿,改善其营养不良状态及保护其心脏功能发挥重要作用,对探索CHD新型的药物治疗方法提供重要参考。文章综述ghrelin对CHD患儿生长发育和心脏功能的影响及意义。

The ghrelin is an endogenous ligand of the growth hormone （GH） seeretagogue receptor, which can regulate the secretion of GH, stimulate the appetite, adjust the energy metabolism, and improve the cardiovascular function. Children with congenital heart disease （CHD） usually suffered from malnutrition and growth retardation, which were connected with insufficiency of energy intake, poor absorption, and increase of nutritional requirement, anatomy and the changes of hemodynamics. Many infants with CHD gradually present ventricular dysfunction and growth restriction in their early childhood, which consequently lead to severe complications. Ghrelin is valuable in the early detection of potential CHD, plays an important role in improving the state of malnutrition and protecting the cardiac function, and provides an important reference to explore the new drug therapy for CHD. This review summarized the effects and significances of ghrelin on growth and cardiac function in infants with CHD.