结直肠癌预后因素的分子生物学研究

Molecular biology study of prognostic factors in colorectal cancer

结直肠癌是常见的恶性肿瘤，其预后受多种因素影响。临床TNM分期在评估患者的预后方面存在明显不足。近年来与结直肠癌预后相关的分子标志物研究取得了显著进展，预后评估逐步向“个体化”发展。本文就结直肠癌预后相关的分子生物学研究进展作一阐述。

Colorectal cancer is a common malignant tumor with high rising incidence rate, and the prognosis is influenced by many factors. The clinical TNM stages have obvious deficiencies in assessment of the prognosis of patients. In recent years, studies on molecular markers have made significant achievements associated with colorectal prognosis, and assessment of the prognosis has developed gradually to ＂individu- alization＂. This paper will summarize the research progress of molecular biology associated with colorectal prognosis.