载阿仑膦酸钠／磷酸钙骨水泥复合体系微观结构的研究

Microstructures of alendronate sodium/calcium phosphate bone cement composites

目的观察载阿仑膦酸钠/磷酸钙骨水泥复合体系中的阿仑膦酸钠药物对磷酸钙骨水泥固化过程以及固化后微观结构的影响。方法制备不同浓度（0.5、1.0、1.5、2.0、2.5、3.0 wt%）负载治疗药物阿仑膦酸钠的磷酸钙骨水泥，分别采用X射线衍射仪、扫描电子显微镜及阿基米德排水法等方法观察阿仑膦酸钠的载入对磷酸钙骨水泥微观结构的影响。结果阿仑膦酸钠的添加对骨水泥水化产物的物相组成上未产生影响；扫描电镜下几组样品微观结构基本相似，多数晶体相互交织成网状结构或融合成板状结构，均呈珊瑚样状结晶体；孔隙率实验证明，随着药物浓度的增加，复合体系孔隙率随之降低，孔隙率依次为（52.5±0.6）%、（43.0±0.4）%、（47.2±0.7）%、（41.3±0.3）%、（36.7±0.5）%、（29.4±0.8）%、（33.6±0.3）%，几组样品间差异有统计学意义（P＝0.032），证明药物的载入可以使基体变得更加致密。结论阿仑膦酸钠的载入对磷酸钙骨水泥的微观结构基本没有影响，磷酸钙骨水泥是阿仑膦酸钠较稳定的药物复合载体。

Objective Observation contains of Alendronate sodium/calcium phosphate cement composite system of Alendronate Sodium on calcium phosphate cement curing process curing effects of micro-structure.Methods Preparation of different concentrations （0.5, 1.0, 1.5, 2.0, 2.5 and 3.0 wt%） load drug Alendronate sodium calcium phosphate cement, using x-ray diffractometer, scanning electron microscope and observation of Archimedes’ methods of drainage of Alendronate Sodium load effects on the microstructure of calcium phosphate bone cement.Results Allan phosphine acid sodium of added on bone cement hydration product of real phase composition Shang not produced effect; scan electric mirror Xia several group samples micro structure basic similar, most Crystal mutual interwoven into mesh structure or fusion into Board-like structure, are is coral sample-like Crystal; pore rate experiment proved, with drug concentration of increased, composite system pore rate with of reduced, pore rate followed by for （52.5±0.6）%, （43.0±0.4）%, （47.2±0.7）%, （41.3±0.3）%, （36.7±0.5）%, （29.4±0.8）%, （33.6±0.3）%, statistically significant difference among the groups of samples （P=0.032）, proving that drug load can make the matrix becomes more dense.Conclusion Alendronate Sodium loading has no effect on microstructure of calcium phosphate cement, calcium phosphate cement drug Alendronate Sodium is more stable complex vector.