依布硒的生理活性及合成方法研究进展

Progress on physiological activities and synthetic methods of ebselen

有机硒类化合物是一类具有广泛生理活性的生物活性物质。依布硒是其代表化合物,它作为谷胱甘肽过氧化物酶的小分子模拟物可以被用于心脑血管疾病、炎症和噪声致听力损伤等多种疾病的治疗。笔者简要综述了依布硒的生理活性和合成方法的研究进展。

Organoselenium compounds are bioactive substances with extensive physiological activities. As a representative compound, ebselen could be used as mimics of glutathione peroxidase, and in the treatment of many diseases, such as cardiovascular and cerebrovascular diseases, inflammation and noise-induced hearing loss. the research progress in physiological activities and synthetic methods of ebselen were reviewed in this paper.