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线粒体DNA异质性 被引量：6

Mitochondrial DNA Heteroplasmy
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摘要 线粒体DNA(mitochondrial DNA,mtDNA)是线粒体内最重要的遗传物质。mtDNA突变普遍存在,突变型mtDNA与野生型mtDNA共存的现象被称为mtDNA异质性。mtDNA异质性与衰老和多种疾病密切相关。mtDNA异质性特性、mtDNA异质性与衰老和疾病相关性以及线粒体疾病的治疗等都是近年来遗传学研究的热点。本文从mtDNA异质性的动态变化、组织特异性、mtDNA异质性与疾病以及线粒体疾病的治疗等方面对mtDNA异质性进行综述。 Mammal mitochondrial DNAs（ mtDNAs） resident in mitochondria. mtDNA mutations are widespread. The co-existence of the wild-type and mutant mtDNAs is called mtDNA heteroplasmy.mtDNA heteroplasmy is closely related to aging and different diseases. Hitherto,characteristics of mtDNA heteroplasmy,the relationship between mtDNA heteroplasmy and aging,the correlation between mtDNA heteroplasmy and disease and the therapy of mitochondrial disease were all research hot pots. In this paper,we reviewed dynamics and tissue-specificity of mtDNA heteroplasmy. And the relation between mtDNA heteroplasmy and aging,mtDNA heteroplasmy and disease and the therapy of mitochondrial disease were also summarized.
作者 巫小倩 张顺华 朱砺
机构地区 四川农业大学动物科技学院
出处 《中国生物化学与分子生物学报》 CAS CSCD 北大核心 2017年第1期11-16,共6页 Chinese Journal of Biochemistry and Molecular Biology
基金 四川省教育厅科研项目(No.16ZB0038) 四川省科技厅项目(No.16ZC2838)资助~~
关键词 mtDNA异质性 动态变化 组织特异性 疾病 治疗 mitochondrial DNA heteroplasmy dynamics tissue-specificity disease therapy
分类号 Q34 [生物学—遗传学]
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中国生物化学与分子生物学报
2017年 第1期

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