β-甲基萘催化氧化合成维生素K3的研究进展

Research progress on the catalytic oxidation of β-methylnaphthalene to vitamin K_3

维生素K_3(VK_3)不仅是合成维生素K类的重要中间体,也是常用医药及饲料添加剂。VK_3只能由人工合成,通过绿色途径直接催化氧化β-甲基萘(β-MN)制备VK_3的工艺一直存在较大难度。本文综述了以双氧水、氧化性盐类、氧气等不同氧化剂催化氧化价格低廉的β-MN制取VK_3的研究,重点介绍了以绿色氧化剂双氧水为主的催化氧化反应的国内外研究进展。提及了气相氧化法、电解氧化法和微波氧化法的最新研究成果。液相和气相氧化法由于具有易操作性及低能耗等特点,应作为VK_3工业生产的首选操作方式。微波氧化法处于基础研究阶段,但是其高效节能、绿色环保的优势引起研究者的广泛关注。最后指出了未来VK_3研发工作在催化剂制备、氧化剂选用、溶剂选取等方面应努力的方向。

Vitamin K3（VK3）,an important intermediate for the synthesis of vitamin K,medicine and feed additive,can be obtained only by the artificial synthesis. β-methylnaphthalene（β-MN） can be directly oxidized to VK3 by green method but with many difficulties. Research on the catalytic oxidation of low-cost β-MN to VK3 by different oxidants,such as hydrogen peroxide,oxidizing salt and oxygen,is reviewed in this paper. The review is focus on the catalytic oxidation reactions using green oxidant,hydrogen peroxide. The latest research results on gas phase oxidation,electrolytic oxidation and microwave oxidation are mentioned. Due to the simple operation and low energy consumption,liquid-phase oxidation and gas phase oxidation should be the first choice for industrial production of VK3. Although the study on microwave oxidation is still at the early stage,the high-efficient and green microwave oxidation has drawn great attention. Finally,some suggestions for future synthesis of VK3,such as preparation of catalyst,selection of oxidants and solvents,are suggested.