大豆磷脂酰聚乙二醇单甲醚2000的制备及性能

Preparation and performance of soybean phosphatidyl methoxy polyethylene glycol 2000 ester

以大豆磷脂为原料,首先制备出大豆磷脂酸钠,再与聚乙二醇单甲醚2000对甲苯磺酸酯(mPEG_2000-OTs)反应制备大豆磷脂酰聚乙二醇单甲醚2000(SP-mPEG_2000)。实验结果为:以65mg Na H处理大豆磷脂得到大豆磷脂酸钠,m(大豆磷脂酸钠)∶m(mPEG_2000-OTs)=0.45∶1,反应时间为4h,反应温度为90℃,转化率为71.2%,产物为淡黄色固体。经~1HNMR和IR表征,证明为SP-mPEG_2000。该合成路线反应条件温和,大豆磷脂利用率高。SP-mPEG_2000水溶液临界胶束浓度为0.5g/L,此时表面张力为42mN/m。通过SP-mPEG_2000对正己烷和水形成的乳状液的稳定性表征,表明产物的动力学稳定性优于大豆粉末磷脂。

With soybean phospholipid as raw material,first it was converted into sodium soy phospholipids and then reacted with monomethoxypolyethylene glycol 2000 tosylate（mPEG2000-OTs） to prepare soybean phosphatidyl methoxy polyethylene glycol 2000 ester（SP-mPEG2000）. The experimental results were as follows： soybean phospholipid was reacted with 65mg NaH to obtain sodium soy phospholipids,m（sodium soy phospholipids）∶m（mPEG2000-OTs） = 0.45∶1,reaction time was 4 hours,reaction temperature was 90℃,and the conversion rate was 71.2%. The solid product is pale yellow color. Analyzed by ^1HNMR and IR,the product was proved to be SP-mPEG2000. This method has the characteristics of mild reaction condition and high utilization of soybean phospholipid. The critical micelle concentration of SP-mPEG2000 is 0.5g/L with surface tension of 42mN/m,The kinetic stability of SP-mPEG2000 was confirmed by emulsifying power of n-hexane and water,which indicated that kinetic stability of the product is superior to soybean phospholipid powder.