213例膝骨关节炎患者中医症候规律分析

Law Analysis of Traditional Chinese Medicine Syndrome in 213 Patients with Knee Osteoarthritis

目的:通过对213例膝骨关节炎(KOA)患者的症候进行聚类分析,找寻症候的分布规律及其诊断要点。方法:参照《中华人民共和国国家标准中医临床诊疗术语证候部分》有关证候判定标准,自制膝骨关节炎中医证型调查表,收集了213例KOA患者。把四诊资料首先进行系统变量聚类分析,再结合临床实际,认为分为3类最为合适,然后再行K均值聚类分析,并对每一类证型进行主成分分析,确定每个证型和对应症状。结论:肝阴虚证、肾阴虚证、脾阳虚证、痰湿证、寒证、风证、血瘀证、气滞证等是膝关节骨关节炎的基本证候单位,肝肾阴虚髓亏证、脾阳虚寒凝痰湿、风寒气滞血瘀是膝关节骨关节炎的常见中医证候类型。

Objective： Through the cluster analysis of 213 patients with osteoarthritis of the knee（ KOA） in patients with symptoms,looking for regularities of distribution and diagnosis of symptoms. Methods： Refering to The Clinical Diagnosis and Treatment of Traditional Chinese Medicine Syndromes in Terms Section of People＇s Republic of China National Standard,our team made knee osteoarthritis in TCM syndrome questionnaire,collected 213 patients with KOA. Firstly,we got the four diagnostic information into systematic cluster analysis of variables,and then considering combining clinical,considering divided into 3types was the most apposite,carrying out K-means cluster analysis,analysis in principal component of every TCM syndromes. Finally,confirming every TCM syndromes and corresponding symptoms. Results： Syndrome of deficiency of the liver-Yin and the kidneyYin,syndrome of deficiency of the spleen-Yang and phlegm-dampness and cold syndrome,wind syndrome,syndrome of blood stasis and stagnation were basic symptoms of osteoarthritis of the knee. Syndrome of marrow,liver and deficiency of the kidney-Yin,syndrome of purplish clots,phlegm-dampness and deficiency of the spleen-Yang and syndrome of cold stagnation and blood stasis were the common TCM syndromes of KOA.