MDM2-309T/G基因多态性与食管癌易感性关系的Meta分析

Association between MDM2-309T/G polymorphism and esophageal carcinoma susceptibility:A Meta-analysis

目的探讨MDM2基因多态性与食管癌易感性关联性。方法计算机检索PubMed、中国生物医学期刊网、中国知网、万方、维普数据库,收集有关双微体基因2(MDM2)基因多态性与食管癌易感性关系的病例对照研究,提取纳入文献的相关数据进行Meta分析,以病例组与对照组MDM2各种模型的比值比(OR)为效应指标,Egger's检验和Bggerg检验发表偏倚。结果共7篇研究符合纳入标准,累计病例组2 206例,对照组3 327例。荟萃分析结果显示:与野生型纯合子(309T/T)基因型个体相比,变异纯合子(309G/G)与杂合子(309G/T)基因型个体中食管癌风险增高且有统计学意义[GG vs.TT:OR=11.64,95%CI10.17~13.31;GT vs.TT:OR=11.07,95%CI10.02~12.22]。在隐性遗传模型中(GG vs.GT/TT)食管癌风险增高有统计学意义[GG vs.GT/TT:OR=1.17,95%CI 1.03~1.32],但在显性遗传模型中(GG/GT vs.TT)发病率风险增高无统计学意义[GG/GT vs.TT:OR=1.02,95%CI0.94~1.11]。在按地区分组的亚组分析中,Meta分析结果显示:MDM2-309T/G基因多态性与中国人群食管癌风险显著相关[GG vs.TT:OR=10.77,95%CI9.35~I2.42,P=0.000;GTvs.TT:OR=10.11,95%CI9.11~11.23,P=0.000;GG vs.GT/TT:OR=7.03,95%CI6.44~7.67,P=0.000;GG/GT vs.TT:OR=5.86,95%CI5.12~6.69,P=0.000]。结论MDM2-309T/G基因多态性与中国人群食管癌风险显著相关,MDM2-309G/G基因型个体食管癌患病风险可能增高。

Objective To explore the association between the MDM 2-309 T/G polymorphism and Esophageal carcino-ma susceptibility .Methods Data bases were comprehensively searched to retrace all the related studies on the associations between MDM2 polymorphism and esophageal carcinoma susceptibility in population .The pooled odds ratios （ORs） with 95%confidence intervals （95%CIs） of the association between MDM2 polymorphism and esophageal carcinoma susceptibility were performed in different genetic model comparison .Publication bias was detected by symmetry of funnel plot .Results Seven o-riginal studies with a total of 5 533 subjects （2 206 patients and 3 327 controls） were entered the final data combination .The results of Meta-analyses showed that the variant homozygote （309G/G genotype） and the variant heterozygote （309T/G geno-type） were significantly associated with an increased risk of esophageal carcinoma as compared to wild type homozygote （309G/G genotype：OR =11.64, 95%CI 10.17 to 13.31;309T/G genotype：OR =11.07, 95%CI 10.02 to 12.22）.A significantly increased risk of esophageal carcinoma was observed for the recessive model （GG vs.TT/TG：OR =1.17, 95%CI 1.03 to 1.32）.While in the dominant model （GG/TG vs.TT）, non-significant association was observed （ OR =1.02, 95%CI 0.94 to 1.11）.In the subgroup analysis by ethnicity , meta-analysis strongly suggests that there are significant associ-ations between MDM2 309T/G polymorphism and esophageal carcinoid susceptibility in Chinese [ GGvs.TT：OR =10.77, 95%CI 9.35, 12.42, P =0.000;GT vs.TT：OR =10.11, 95%CI 9.11, 11.23, P =0.000; GG vs.GT/TT：OR =7.03, 95%CI 6.44, 7.67, P =0.000;GG/GT vs.TT：OR =5.86, 95%CI 5.12, 6.69, P =0.000].Conclusion The MDM2-309 GG may contribute to esophageal carcinoma in Chinese population .