定量动态增强磁共振技术的影响因素分析

Analysis of the main factors affecting quantitative dynamic contrast-enhanced MR imaging

动态增强磁共振成像(dynamic contrast-enhanced MRI,DCE-MRI)基于快速T1WI,行多期动态增强扫描,获取感兴趣区时间-信号强度曲线,再通过药代动力学模型分析,得到反映组织灌注及血管渗透性的定量参数,已应用于肿瘤诊断、疗效评价、预后评估。作者针对影响DCE-MRI结果的主要因素:扫描方案、动脉输入函数(arterial input functions,AIF)、运动位移、药代动力学模型,进行系统评价,通过提高DCE-MRI参数的可重复性和准确性,为临床应用提供帮助。

DCE-MRI is based on the serial acquisition of the fast T1W1. Through multi-phase contrast enhanced scanning, the time-signal intensity curve of the region- of-interest （ROI） can be acquired. Meanwhile, the quantitative parameters reflecting tissue perfusion and vascular permeability are obtained by selecting the proper pharmacokinetic model. This method has been widely applied in many clinical aspects, including tumor diagnosis, assessment of therapeutic response and prognostic evaluation. In this paper, we conducted a systematic review focused on main factors that may influence DCE-MRI outcomes. These factors include scanning protocol, arterial input functions （AIF）, the motion displacement and the pharmacokinetic models. Optimizing these main factors may improve the reproducibility and accuracy of the DCE-MRI results.