全胰十二指肠切除术治疗胰腺癌28例分析

Analysis of total pancreaticoduodenectomy in 28 patients with pancreatic cancer

目的对全胰十二指肠切除术治疗胰腺癌的疗效进行评价。方法收集宁波市医疗中心李惠利医院2009年1月至2015年3月接受全胰十二指肠切除的28例患者资料并进行回顾分析。结果28例患者术后并发症发生率39．2％（11例），其中胰腺癌Grade Ⅱ级7例，GradeⅢ级4例。无术后30天内死亡患者。25例患者得到随访，中位生存期为13．5个月，其中24例胰腺导管腺癌患者中位生存期为13个月。结论全胰十二指肠切除术后患者生存期虽无明显提高，但术后并发症下降，术后生活质量得到保证。在部分选择病例中，全胰十二指肠切除手术可作为合理的手术方式。

Objective To study the clinical outcomes of 28 pancreatic cancer patients who under- went total pancreaticoduodenectomy. Method The clinical data of 28 patients with pancreatic cancer who underwent total panereaticoduodenectomy from January 2009 to March 2015 were retrospectively analyzed. Results Among the 28 patients, complications occurred in 11 （39.2%） after the operation. There were 7 patient having Grade Ⅱ, 4 Grade Ⅲ complications. No patient died within 30 days after the operation. Follow-up of 25 patients showed a median survival of 13.5 months. There were 24 patients with pancreatic duc- tal adenocarcinoma, and the median survival was 13 monlhs. Conclusions Total pancreaticoduodenectomy could not improve long-term survival but it decreased postoperative complications and improved postoperative quality of life. In selected patients, total pancreaticoduodenectomy could be a rational option.