摘要
目的测定非酒精性脂肪肝病(NAFLD)患者血清中视黄酸受体反应蛋白2(chemerin)、超敏C反应蛋白(hs-CRP)的表达水平,以及胰岛素抵抗指数(HOMA-IR),探讨chemerin在NAFLD发病中的机制。方法将NAFLD患者分为两组,NAFLD组(30例)和NAFLD+IR组(30例);并选择健康体检者30例作为健康对照组。用双抗体夹心酶联免疫吸附法检测血清chemerin,免疫比浊法检测血清hs-CRP,同时测定空腹血糖(FPG)、空腹胰岛素(FINS),并计算胰岛素抵抗指数(HOMA-IR)。结果与健康对照组相比较,NAFLD组患者的血清chemerin和hs-CRP水平明显升高(P<0.05)。与健康对照组和NAFLD组比较,NAFLD+IR组患者的血清chemerin和hs-CRP水平也明显升高(P<0.05)。血清chemerin水平与hs-CRP、HOMA-IR呈显著正相关。结论 NAFLD患者的血清chemerin水平与hs-CRP、HOMA-IR相关。
Objective To detect the serum levels of chemerin and high-sensitivity C-reactive protein(hs-CRP)in the patients with nonalcoholic fatty liver disease(NAFLD)and homeostasis model assessment of insulin resistance(HOMA-IR),and to investigate the mechanism of chemerin in NAFLD.Methods The patients with NAFLD were divided into the NAFLD group(30cases)and the NAFLD+IR group(30cases);other 30 individuals undergoing the healthy physical examination were selected as the healthy control group.The serum levels of chemerin and hs-CRP were measured by ELISA and immunoturbidimetry,respectively.Meanwhile,the fasting plasma glucose(FPG)and fasting insulin(FINS)were detected,and HOMA-IR was calculated.Results The levels of serum chemerin and hs-CRP in the NAFLD group were increased obviously compared with the healthy control group(P〈0.05).The levels of serum chemerin and hs-CRP in the NAFLD+IR group were significantly increased compared with the NAFLD group and healthy control group(P〈0.05).The serum chemerin level was positively correlated with the hs-CRP level and HOMAIR.Conclusion The serum chemerin level is correlated with hs-CRP and HOMA-IR in NAFLD patients.
出处
《重庆医学》
CAS
北大核心
2017年第2期172-174,共3页
Chongqing medicine
基金
广西教育厅科研基金资助项目(2013LX075
2013LX077)
广西卫生厅科研基金资助项目(Z2013489)
广西桂林市卫生局科学研究与技术开发计划资助项目(20120121-1-14)