卵巢癌组织中PTEN和P53蛋白的表达及其与卵巢癌临床特点的关系

Expression of PTEN and P53 protein in ovarian cancer tissue and its relationship with clinical characteristics of ovarian cancer

目的对卵巢癌组织中PTEN和P53蛋白的表达情况进行研究,探讨其与卵巢癌临床特点的关系。方法选择2013年12月至2014年12月吉林大学第一医院肿瘤妇科手术切除卵巢上皮癌标本50例和正常卵巢组织标本50例作为研究对象,免疫组织化学染色法测定组织中PTEN和P53的表达情况,观察卵巢癌组织中PTEN和P53的表达和卵巢癌临床特点的关系。结果卵巢癌组织中PTEN阳性率明显低于正常卵巢组织(P<0.05),P53阳性率明显高于正常卵巢组织(P<0.05)。卵巢癌Ⅱ期和Ⅲ~Ⅳ期的PTEN阳性率明显低于Ⅰ期,高分化卵巢癌组织中PTEN阳性率明显高于低分化和中分化卵巢癌组织(P<0.05)。卵巢癌Ⅱ期和Ⅲ~Ⅳ期的P53阳性率明显高于Ⅰ期(P<0.05),低分化卵巢癌组织中P53阳性率明显高于中分化和高分化卵巢癌组织(P<0.05)。结论卵巢癌组织中PTEN表达降低,P53表达升高,PTEN和P53的表达和卵巢癌的临床分期及分化程度关系密切。

Objective To study the expressions of PTEN and P53 protein in ovarian cancer tissue and to investigate their relationship with the clinical characteristics of ovarian cancer.Methods Fifty specimens of operatively resected ovarian epithelial cancer and 50 specimens of normal ovarian tissue in the First Hospital of Jilin University from December 2013 to December 2014 were selected as the study objects.The expressions of PTEN and P53 in ovarian cancer tissue were examined by immunohistochemical staining method.The relationship between the PTEN and P53 expressions with the clinical characteristics of ovarian cancer were observed.Results The PTEN positive rate of ovarian cancer tissue was significantly lower than that of normal ovarian tissue（P〈0.05）.The P53 positive rate of ovarian cancer tissue was significantly higher than that of normal ovarian tissue（P〈0.05）.The PTEN positive rate of ovarian cancer stageⅡ and stageⅢ-Ⅳ was lower than that of stageⅠ（P〈0.05）.The PTEN positive rate of well-differentiated ovarian cancer tissue was higher than that of moderately differentiated and poorly differentiated tissue（P〈0.05）.The P53 positive rate of ovarian cancer stageⅡandⅢ-Ⅳ was significantly higher than that of stageⅠ（P〈0.05）,the P53 positive rate of poorly differentiated ovarian cancer tissue was higher than that of moderately differentiated and well-differentiated tissue（P〈0.05）.Conclusion The PTEN expression in ovarian cancer tissue is decreased and the P53 expression is increased,the expression of PTEN and P53 is closely related to the clinical stage and differentiation degree of ovarian cancer.