持续大剂量静脉泵入654-2治疗中重症急性胰腺炎的疗效观察

The Curative Effect Observation of Continuous High-dose Intravenous Pumping 654-2 for Patients with Moderately Severe Acute Pancreatitis

目的:探讨持续大剂量静脉泵入654-2治疗中重症急性胰腺炎的疗效,为临床提供参考。方法:收集我院2013年1月—2016年6月收治的70例中重症急性胰腺炎患者作为研究对象,按照治疗方案的不同,分为对照组和观察组,对照组采用综合治疗措施,观察组是在综合治疗的基础之上给予持续大剂量654-2静脉泵入。对两组的疗效及相关实验室指标进行比较分析。结果:观察组腹痛腹胀消失时间、禁食时间、持续胃肠减压时间、排便时间、住院天数及住院费用等指标均优于对照组,差异有统计学意义(P<0.05)。治疗后1周,观察组血尿淀粉酶、C-反应蛋白(CRP)及白介素-6(IL-6)等实验室指标均低于对照组,差异有统计学意义(P<0.05)。结论:在综合治疗的基础上,给予持续大剂量静脉泵入654-2治疗中重症急性胰腺炎疗效显著,值得临床推广应用。

Objective：To explore the curative effect observation of continuous high-dose intravenous pumping 654-2for patients with moderately severe acute pancreatitis,it provides the reference for clinical.Methods：70cases of patients with Moderately severe acute pancreatitis were analyzed from January 2013 to June 2016,According to the different treatment,they were divided into control group and observation group,control group adopted comprehensive treatment measures,observation group had a treat of continuous high-dose 654-2intravenous pumping on the basis of comprehensive treatment.The curative effect and related laboratory indexes of two groups were compared.Results：Abdominal pain and abdominal distention disappear time,fasting,gastrointestinal decompression duration,defecation time,hospitalization days and the hospitalization expenses of two groups had a comparison.The difference was statistically significant（P〈0.05）.After 1week treatment,blood and urine amylase,C-reactive protein（CRP）and interleukin 6（IL-6）of inter-and intra-groups were compared,the difference was statistically significant（P〈0.05）.Conclusion：On the basis of comprehensive treatment,it was remarkable for patients with Moderately severe acute pancreatitis to give continuous high-dose intravenous pumping 654-2.This method is worthy of clinical application.