人乳头瘤病毒与鼻腔鼻窦癌关系的研究进展

Research Progress of Relationship between the Human Papillomavirus and the Sinonasal Carsinoma

人乳头瘤病毒(HPV)易于感染人类鳞-柱交界区周围黏膜组织,其致癌作用与p53、Rb蛋白、p16以及微小染色体维持蛋白家族成员等多种细胞因子有关,涉及人体多个系统。HPV感染与鼻腔鼻窦内翻性乳头状瘤和恶性肿瘤的发生、发展密切相关,而且其感染与否可能对患者预后产生影响。因此,研究HPV的致癌作用机制,对鼻腔鼻窦恶性肿瘤患者的指导治疗和预后判断具有重要意义。

Human papilloroavirus（HPV） may easily infeet human roueosa tissue around the junction of the squamous and columnar epithelium,and its eareinogenie effeet is related to p53, retinoblastoma protein（ Rb protein）, p16 and miniehromosoroe maintenance protein of family members and other cell faetors involving multiple human systems. HPV infection is closely related to the oeeurrenee and development of sinonasal inverted papilloma and the malignant tumor, and the infeetion may have an iropaet on the prognosis of the patients. Therefore, it is of great significance to study the eareinogenie meehanisro of HPV in patients with the sinonasal malignant tumor.