微小RNA对肠道健康的影响及作用机制

MicroRNAs: Effects on Intestinal Health and Its Mechanisms

肠道既是机体营养物质消化吸收的主要场所,也是防御肠道微生物感染的先天性屏障,肠道健康是机体正常生长发育的关键。微小RNA(miRNAs)是基因转录后调控的重要因子。本文主要对肠道miRNAs表达情况,miRNAs在肠道细胞中的增殖、分化、凋亡,miRNAs在营养代谢、肠道屏障功能、肠道相关疾病进程调控中的作用以及肠道对外源miRNAs摄取等方面的研究进行综述,以期为相关研究的开展提供参考。

Intestine is the major organ of digesting and absorbing nutrients and plays an important role in protecting body against from bacterial infection. MicroRNAs（ miRNAs） serve as important intracellular factor in post-transcriptional regulation of gene expression. In this paper,in order to provide reference for further study,we summarized recent researches in the expression of miRNAs in intestinal tissue,the effects of miRNAs on proliferation,differentiation and apoptosis of intestinal cells,the regulatory function on nutrient metabolism,intestinal barrier function and disease progression,and the absorption of external miRNAs in intestine.